Why Should I Take Pyridoxal-5'-Phosphate?
If you are interested in supplementing with vitamin B6, then skip the pyridoxal HCL and go straight for the active form, Pyridoxal-5'-Phosphate (P5P)! P5P produces all of the vitamin B6 benefits, but much more efficiently than the more commonly used Pyridoxal HCL, making P5P the ideal B6 supplement!
If you are not familiar with vitamin B6 and its long list of benefits, you may be asking yourself, why would I be interested in the best form of vitamin B6? The simple answer to this is neurotransmitter support! P5P plays a crucial role in the synthesis of serotonin, GABA, norepinephrine and epinephrine making this a vitamin that can have a noticeable impact on mood, focus and cognitive function.
What is Pyridoxal-5'-Phosphate?
Pyridoxal-5'-Phosphate, also referred to as P5P, is the bioactive form of vitamin B6. Within the body and brain, P5P acts as a coenzyme, driving many different enzyme dependent reactions. Most interestingly the enzymes responsible for serotonin synthesis require P5P as a coenzyme. In addition to serotonin, GABA is another neurotransmitter which relies heavily on the presence of P5P for its synthesis. Last but not least, P5P is also necessary for the conversion of L-DOPA to dopamine. This means that P5P plays a crucial role in maintaining overall neurotransmitter balances.
Let’s now dive into the benefits of P5P!
Pyridoxal-5'-Phosphate Benefits & Uses
- Supports neurotransmitter synthesis
- Promotes cognitive function
- Helps regulate prolactin levels
The Ultimate Neurotransmitter Supplement
P5P plays a major role in neurotransmitter synthesis but we need to cover some steps to show how it does this! Vitamin B6 plays a major role in the metabolism of amino acids through decarboxylation, transamination, deammation, racemization and desulfhydration reactions. This is very important because most neurotransmitters are derived from amino acids. For example, serotonin is synthesized from the amino acid L-Tryptophan. L-Tryptophan, via the enzyme tryptophan hydroxylase, is converted to 5-hydroxytryptophan (5-HTP). 5-HTP is then converted in a single step to serotonin by another enzyme called aromatic L-amino acid decarboxylase (AADC). AADC depends on P5P, which means that without P5P, you cannot complete the last step in serotonin synthesis. This very same enzyme, also generates the following neurotransmitters and neuromodulators
This means that without P5P, any neurotransmitter or neuromodulator that is synthesized by AADC, will not be produced.
In addition to AADC, another enzyme called glutamic acid decarboxylase (GAD), is heavily dependent on P5P. GAD converts the excitatory amino acid neurotransmitter glutamate to the inhibitory amino acid neurotransmitter GABA. This means that P5P is also crucial for maintaining the balance between glutamate and GABA in the brain.
Finally, P5P also regulates prolactin levels, a hormone which also has a close relationship with dopamine. When dopamine levels drop, prolactin levels can increase which can have undesirable physical and mental effects. This is where P5P can really shine, as it both limits the release of prolactin, while also enhancing dopamine levels!
The overall effects you may experience then from P5P, is a better mood, sleep and focus. This will be especially noticeable if you are deficient in vitamin B6.
The Cognitive Stack: Pyridoxal-5'-Phosphate + ClariMAG Capsules
ClariMAG is our optimized magnesium supplement that was specifically designed to bring you the best of mental clarity. ClariMAG also contains vitamin C, which is then turned into threonic acid to further advance the brain magnesium content! When paired with Pyridoxal-5'-Phosphate, you will be replenishing essential minerals and B vitamins, which have the added benefit of improving mental clarity and mood!
The Neurotransmitter Stack: Pyridoxal-5'-Phosphate + L-Tyrosine Capsules
L-Tyrosine is a precursor to L-DOPA, and L-DOPA gets converted to dopamine by AADC, which as we discussed earlier, is a P5P dependent enzyme. Thus, by combining L-Tyrosine with P5P, dopamine synthesis will be even more efficient!
The Prolactin Stack: Pyridoxal-5'-Phosphate + Apigenin Capsules
Apigenin is another great choice for helping to regulate prolactin levels. Together with P5P, apigenin makes for a very comprehensive prolactin modulating stack!
As a dietary supplement, take one 50mg capsule of Pyridoxal-5'-Phosphate daily.
To gain more insight, see the Pyridoxal-5'-Phosphate reviews and experiences below.
Where to Buy Pyridoxal-5'-Phosphate
Nootropics Depot offers 90ct. or 365ct. jars of high-quality Pyridoxal-5'-Phosphate. Nootropics Depot’s Pyridoxal-5'-Phosphate has been lab-tested and verified for both product purity and identity.
Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.