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Pyridoxal-5'- Phosphate Capsules (P5P) | 50mg | Active Form of Vitamin B6

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SKU:
ND1384A
ACTIVE INGREDIENT:
Pyridoxal-5'- Phosphate
ITEM TYPE:
Capsules
QUANTITY PER BOTTLE:
90ct. or 365ct.
SERVINGS PER BOTTLE:
90 Servings or 365 Servings
SUGGESTED USE:
As a dietary supplement, take one 50mg capsule of Pyridoxal-5 Phosphate daily.
STORAGE:
Store in a cool and dry place. Keep away from direct sunlight and heat.
WARNING:
Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drugs or over the counter medications.
DISCLAIMER:
Always consult with a qualified health physician before taking any new dietary supplement. This product is not intended to diagnose, treat, cure, or prevent any diseases. These statements have not been evaluated by the Food and Drug Administration.

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Pyridoxal-5'- Phosphate Capsules (P5P) | 50mg | Active Form of Vitamin B6
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Description

Why Should I Take Pyridoxal-5'-Phosphate?

If you are interested in supplementing with vitamin B6, then skip the pyridoxal HCL and go straight for the active form, Pyridoxal-5'-Phosphate (P5P)! P5P produces all of the vitamin B6 benefits, but much more efficiently than the more commonly used Pyridoxal HCL, making P5P the ideal B6 supplement!

If you are not familiar with vitamin B6 and its long list of benefits, you may be asking yourself, why would I be interested in the best form of vitamin B6? The simple answer to this is neurotransmitter support! P5P plays a crucial role in the synthesis of serotonin, GABA, norepinephrine and epinephrine making this a vitamin that can have a noticeable impact on mood, focus and cognitive function.

What is Pyridoxal-5'-Phosphate?

Pyridoxal-5'-Phosphate, also referred to as P5P, is the bioactive form of vitamin B6. Within the body and brain, P5P acts as a coenzyme, driving many different enzyme dependent reactions. Most interestingly the enzymes responsible for serotonin synthesis require P5P as a coenzyme. In addition to serotonin, GABA is another neurotransmitter which relies heavily on the presence of P5P for its synthesis. Last but not least, P5P is also necessary for the conversion of L-DOPA to dopamine. This means that P5P plays a crucial role in maintaining overall neurotransmitter balances.
Let’s now dive into the benefits of P5P!

Pyridoxal-5'-Phosphate Benefits & Uses

  • Supports neurotransmitter synthesis
  • Promotes cognitive function
  • Helps regulate prolactin levels

The Ultimate Neurotransmitter Supplement

P5P plays a major role in neurotransmitter synthesis but we need to cover some steps to show how it does this! Vitamin B6 plays a major role in the metabolism of amino acids through decarboxylation, transamination, deammation, racemization and desulfhydration reactions. This is very important because most neurotransmitters are derived from amino acids. For example, serotonin is synthesized from the amino acid L-Tryptophan. L-Tryptophan, via the enzyme tryptophan hydroxylase, is converted to 5-hydroxytryptophan (5-HTP). 5-HTP is then converted in a single step to serotonin by another enzyme called aromatic L-amino acid decarboxylase (AADC). AADC depends on P5P, which means that without P5P, you cannot complete the last step in serotonin synthesis. This very same enzyme, also generates the following neurotransmitters and neuromodulators

  1. Dopamine
  2. Histamine
  3. Phenethylamine
  4. Tyramine
  5. Tryptamine

This means that without P5P, any neurotransmitter or neuromodulator that is synthesized by AADC, will not be produced.

In addition to AADC, another enzyme called glutamic acid decarboxylase (GAD), is heavily dependent on P5P. GAD converts the excitatory amino acid neurotransmitter glutamate to the inhibitory amino acid neurotransmitter GABA. This means that P5P is also crucial for maintaining the balance between glutamate and GABA in the brain.

Finally, P5P also regulates prolactin levels, a hormone which also has a close relationship with dopamine. When dopamine levels drop, prolactin levels can increase which can have undesirable physical and mental effects. This is where P5P can really shine, as it both limits the release of prolactin, while also enhancing dopamine levels!

The overall effects you may experience then from P5P, is a better mood, sleep and focus. This will be especially noticeable if you are deficient in vitamin B6.

Pyridoxal-5'-Phosphate Stacks

The Cognitive Stack: Pyridoxal-5'-Phosphate + ClariMAG Capsules

ClariMAG is our optimized magnesium supplement that was specifically designed to bring you the best of mental clarity. ClariMAG also contains vitamin C, which is then turned into threonic acid to further advance the brain magnesium content! When paired with Pyridoxal-5'-Phosphate, you will be replenishing essential minerals and B vitamins, which have the added benefit of improving mental clarity and mood!

The Neurotransmitter Stack: Pyridoxal-5'-Phosphate + L-Tyrosine Capsules

L-Tyrosine is a precursor to L-DOPA, and L-DOPA gets converted to dopamine by AADC, which as we discussed earlier, is a P5P dependent enzyme. Thus, by combining L-Tyrosine with P5P, dopamine synthesis will be even more efficient! 

The Prolactin Stack: Pyridoxal-5'-Phosphate + Apigenin Capsules

Apigenin is another great choice for helping to regulate prolactin levels. Together with P5P, apigenin makes for a very comprehensive prolactin modulating stack!

Pyridoxal-5'-Phosphate Dosage

As a dietary supplement, take one 50mg capsule of Pyridoxal-5'-Phosphate daily.

Pyridoxal-5'-Phosphate Reviews

To gain more insight, see the Pyridoxal-5'-Phosphate reviews and experiences below.

Where to Buy Pyridoxal-5'-Phosphate

Nootropics Depot offers 90ct. or 365ct. jars of high-quality Pyridoxal-5'-Phosphate. Nootropics Depot’s Pyridoxal-5'-Phosphate has been lab-tested and verified for both product purity and identity.

Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

3 Reviews

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  • Deron "bluMidge" - 18th Nov 2022

    5
    p5p is GooooooooD

    I've only been supplementing p5p for about 3 weeks. I usually take it in the afternoons at work, and I find that it really helps with the afternoon slump that occurs from time to time. A couple of three important reasons to take p5p: it is necessary for the production of neurotransmitters that support a balanced mood, promotes a more positive mental outlook, and helps facilitate a healthy response to stress. And the last one, facilitating a healthy response to stress, is really profound to me because of the line of work I'm in which is sales. I highly recommend p5p from my favorite nootropics company in the entire world. And I would be remiss not to mention, I made an order last night, and it's already out the door. Kudos as always my friends, and thank you for staying ahead of the curb, and doing it with INTEGRITY

  • Carol Test - 26th Sep 2022

    5
    Great Product!

    I really like this product!

3 Reviews

  • Deron "bluMidge" - 18th Nov 2022

    5
    p5p is GooooooooD

    I've only been supplementing p5p for about 3 weeks. I usually take it in the afternoons at work, and I find that it really helps with the afternoon slump that occurs from time to time. A couple of three important reasons to take p5p: it is necessary for the production of neurotransmitters that support a balanced mood, promotes a more positive mental outlook, and helps facilitate a healthy response to stress. And the last one, facilitating a healthy response to stress, is really profound to me because of the line of work I'm in which is sales. I highly recommend p5p from my favorite nootropics company in the entire world. And I would be remiss not to mention, I made an order last night, and it's already out the door. Kudos as always my friends, and thank you for staying ahead of the curb, and doing it with INTEGRITY

  • Carol Test - 26th Sep 2022

    5
    Great Product!

    I really like this product!

  • HZ - 24th Aug 2022

    5
    Vigor, Strength, and Endurance

    So I don't truly know/understand the mechanism of Vitamin b6 (p5p active form) but I heard it is good for lowering prolactin (when it is high) and good for the synthesis of neurotransmitters so why not I figured. Honestly 46 dollars (with shipping) is definitely worth it because the first day i tried it I had insane vigor when working out at the gym. My gym workouts are challenging and I always push myself. But this supplement made effort feel really really good. I am not a chemist but I can say that this really helped me and I will continue to be a part of my supplement stack. If you are thinking of buying it, run it with ksm-66 (ashwaganda) and you will feel amazing trust me! 

I wouldn’t get p5p anywhere else since nootropics depot has a really good reputation of lab quality so spend the extra dollars don’t go cheap. Health is first.

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