About Sabroxy Tablets

Sabroxy® is a premium standardized extract derived from the bark of Oroxylum indicum, delivering exactly 10% oroxylin-A, the key bioactive compound responsible for its cognitive function benefits. This flavone crosses the blood-brain barrier efficiently to support focus, memory, and mental energy. Unlike generic Oroxylum extracts that vary wildly in potency, our precision standardization ensures consistent, reliable results with every serving.

Our Sabroxy Story

The cognitive supplement market was flooded with inconsistent Oroxylum extracts that delivered unpredictable results, leaving customers frustrated and unsure of what they were actually getting. This ancient Ayurvedic ingredient, treasured for over 2,000 years for promoting mental clarity, deserved better than the hit-or-miss formulations available.

We partnered directly with Sabinsa, the developers of the original clinically-studied Sabroxy extract, to bring you a standardized formula that bridges centuries of traditional wisdom with modern neuroscience research. Our approach ensures you get precisely 10% oroxylin-A in every batch, verified by independent third-party testing, so you can experience the consistent cognitive benefits that make this flavone so remarkable for supporting mental performance.

Benefits

• Promotes Overall Cognitive Function: Sabroxy supports comprehensive brain health through multiple pathways, with oroxylin-A enhancing dopamine signaling and supporting healthy neurotransmitter activity for sustained mental performance improvements.
• Improves Mood: The extract helps maintain balanced mood throughout the day by supporting healthy dopamine function and neurological pathways in the brain.
• Improves Focus: Clinical research demonstrates sustained improvements in focus, motivation, and mental energy through enhanced dopamine signaling pathways.
• Improves Memory: Studies show participants experienced significant improvements in episodic memory, immediate word recall, and numeric working memory compared to placebo groups.

Sabroxy also provides comprehensive wellness support by helping regulate inflammatory pathways throughout the body. This dual-action approach makes it valuable for long-term brain health maintenance, with many users reporting improvements in skin clarity and overall well-being alongside enhanced mental performance.

Quality and Standardization

• Direct Sabinsa Partnership: We source Sabroxy directly from Sabinsa, the developers of the original standardized Oroxylin-A extract that has been clinically studied, ensuring you get precisely 10% Oroxylin-A in every batch.
• Third-Party Laboratory Testing: Each batch is sent to independent laboratories for comprehensive analysis that verifies active compound levels of Oroxylin-A and checks for potential contaminants like heavy metals and residual solvents.
• Certificate of Analysis Transparency: We make our Certificates of Analysis available so you can see exactly what's in your supplement, with batch-testing policies that exceed industry norms.
• Climate-Controlled Storage: Products are stored under climate-controlled conditions, preserving potency from manufacturing to delivery.

Mechanism of Action

• Dopamine System Support: Oroxylin-A supports healthy dopamine function and maintains neurotransmitter balance for steady focus and motivation without overstimulating effects.
• GABA-A Receptor Modulation: The compound modulates GABA-A receptor activity, which promotes mental clarity and alertness to support enhanced productivity throughout the day.
• BDNF Enhancement: Oroxylin-A boosts brain-derived neurotrophic factor (BDNF), a key protein involved in learning, memory formation, and synaptic growth for long-term brain health.
• Neuroplasticity Pathways: By encouraging neurogenesis and efficient brain signaling through MAPK-ERK and CREB pathways, Sabroxy helps your mind adapt and perform more effectively over time.
• Healthy Inflammation Response: The extract supports healthy inflammation management, which scientists now connect with optimal brain health and overall well-being including skin appearance.

Overview of the Science

Sabroxy stands on a solid scientific foundation that blends traditional use with modern research. Several peer-reviewed clinical trials and laboratory investigations have explored its effect on cognitive wellness. In a double-blind, placebo-controlled study spanning 12 weeks, adults taking Sabroxy demonstrated statistically significant improvements in learning speed, numeric working memory, and verbal recall—all key measures of cognitive function [1]. Importantly, the safety profile recorded in these trials aligns with longstanding traditional use, supporting Sabroxy's reputation as a safe addition to daily wellness routines.

Preclinical research adds further depth, revealing how oroxylin-A, the principal compound in Sabroxy, helps support brain health through multiple scientific pathways. Oroxylin-A promotes brain-derived neurotrophic factor (BDNF) expression via CREB pathway activation [2][3]. BDNF is widely recognized for its role in encouraging neural growth, synaptic plasticity, and memory formation [7]. This mechanism helps explain users' reports of cumulative cognitive benefits, as consistent support of BDNF may foster long-term brain adaptability and resilience. Sabroxy's influence extends beyond cognition. Recent studies investigate its role in supporting balanced immune and inflammatory responses, measuring widely recognized inflammatory markers such as TNF-α, IL-1β, COX-2, and the NF-κB pathway [4]. In vivo studies found oroxylin-A supports balanced inflammation through regulating SHCBP1 [5]. Oroxylin-A's ability to maintain healthy levels of these biomarkers offers a scientific basis for its holistic benefits, as healthy inflammation profiles are increasingly linked to overall brain and body wellness.

Mood support is another intriguing area of research, with laboratory studies highlighting increased BDNF levels, which are associated with emotional balance and mental well-being [6]. Enhanced neuroplasticity helps foster a resilient mindset, better adaptability to stress, and improved everyday mood. Together, these findings underscore why Sabroxy appeals to health-conscious individuals aiming for comprehensive cognitive support.

[1] Scholey A, Ossoukhova A, Owen L, et al. Effects of an Oroxylum indicum Extract (Sabroxy®) on Cognitive Function in Adults With Self-reported Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Study. Front Aging Neurosci. 2021;13:728360.

[2] Jeon SJ, Rhee SY, Seo JE, et al. Oroxylin A increases BDNF production by activation of MAPK-CREB pathway in rat primary cortical neuronal culture. Neurosci Res. 2011;69(3):214-222.

[3] Jeon SJ, Seo JE, Oh J, et al. Oroxylin A Induces BDNF Expression on Cortical Neurons through Adenosine A2A Receptor Stimulation: A Possible Role in Neuroprotection. Biomol Ther. 2013;21(6):423-430.

[4] Chen YC, Shen SC, Lee WR, et al. Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation. Biochem Pharmacol. 2000;59(11):1445-1457.

[5] Huang H, Cai H, Zhang L, et al. Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice. Int Immunopharmacol. 2020;80:106123.

[6] Xu Q, Li J, Chen X, et al. Antidepressant-like activity of oroxylin A in mice models of depression: A behavioral and neurobiological characterization. Front Pharmacol. 2022;13:921553.

[7] Kim DH, Park SJ, Park DH, et al. Oroxylin A enhances memory consolidation through the brain-derived neurotrophic factor in mice. Behav Brain Res. 2015;279:37-44.

Ingredients

Sabroxy® (Oroxylum indicum bark extract):

• Oroxylum indicum bark extract
• Standardized to minimum 10% Oroxylin-A
• 100mg per serving

Sabroxy® represents the gold standard in Oroxylum indicum extracts, standardized to deliver a minimum of 10% oroxylin-A, the primary bioactive flavone responsible for cognitive benefits. This precise standardization ensures consistent potency across every batch, unlike generic extracts that can vary wildly in their active compound content. The 10% oroxylin-A standardization maximizes bioavailability and efficacy, allowing this remarkable compound to efficiently cross the blood-brain barrier and deliver reliable cognitive support with every serving.