Buying supplements can be confusing, but it doesn't have to be.
Let us take the guess work out of analyzing the research, so you can understand the science behind Saffron's potential benefits.
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Saffron Primary Benefits
Mood
Neuroprotection
Cognition
Oxidation
The studies highlighted below are based on general research of Saffron, not specifically on Nootropics Depot's product. Saffron can come in many forms and standardizations, and not all of them have the same efficacy. This research snapshot is intended to highlight the current state of the science regarding Saffron, and should not be construed as direct evidence for the clinical efficacy of any one specific product.
Can Saffron Improve Mood?
Summary
TThese studies suggest that saffron can improve mood by supporting healthy stress levels.
We've highlighted the some of the relevant studies below.
Affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial.
Affron®, a saffron extract, significantly decreased negative mood and symptoms related to stress.
Complementary therapies in medicine | Graham Kell et al. | 60 citations | 2017
Randomized Controlled Trial
Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel Group, Clinical Trial
Saffron extract appears to improve symptoms in healthy individuals and may contribute to increased resilience against stress.
Frontiers in Nutrition | P. Jackson et al. | 22 citations | 2021
Randomized Controlled Trial
Saffron for supporting mental well-being: Current evidence and potential mechanisms of action.
Saffron may have mood-enhancing effects and serves as an effective and safe option for promoting emotional well-being.
Journal of affective disorders | Mojtaba Shafiee et al. | 107 citations | 2018
Rigorous Journal
Highly Cited
Systematic Review
Affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of stress: A randomised, double-blind, placebo-controlled study.
Saffron extract (affron®) improved stress in youth with mild-to-moderate symptoms, according to adolescent self-reports.
Journal of affective disorders | Adrian L. Lopresti et al. | 43 citations | 2018
Randomized Controlled Trial
Rigorous Journal
Does Saffron Improve Cognitive Function?
Summary
We've highlighted the some of the relevant studies below.
Association between chronic stress and memory: Therapeutic effects of Saffron.
Saffron and its main component crocin are effective in supporting cognitive function under prolonged stress and reducing oxidative stress, while also helping to maintain cognitive health as individuals age.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | Mohammad Saeedi et al. | 34 citations | 2020
Systematic Review
Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection
Saffron administration in mice led to significant improvement in learning and memory, accompanied by reduced lipid peroxidation products and higher antioxidant activity.
Behavioural Brain Research | Magdalini A. Papandreou et al. | 194 citations | 2011
Non Randomized Controlled Trial
Animal Trial
Highly Cited
Neuroprotective effects of saffron on the late cerebral ischemia injury through inhibiting astrogliosis and glial scar formation in rats.
Saffron ameliorated stress state and cognitive function in rats after cerebral ischemia.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | Kai Zhong et al. | 20 citations | 2020
Rigorous Journal
Highly Cited
Randomized Controlled Trial
Association of Crocus sativus with Cognitive Impairments and Cognitive Decline: A Systematic Review.
Saffron and its major constituents have remarkable properties on memory and cognitive deficiency, suggesting potential support for cognitive function.
Biointerface Research in Applied Chemistry | M. Talebi et al. | 13 Citations | 2020
Systematic Review
Can Saffron Offer Neuroprotection?
Summary
We've highlighted the some of the relevant studies below.
Protective properties of the aqueous extract of saffron (Crocus sativus L.) randomized clinical trial.
Saffron extract has short and long-term neuroprotective effects in humans.
Journal of Ethnopharmacology | Mostafa Asadollahi et al. | 19 citations | 2019
Randomized Controlled Trial
Neuroprotective effects of saffron on the late cerebral ischemia injury through inhibiting astrogliosis and glial scar formation in rats.
Saffron exerted neuroprotective effects on late cerebral ischemia by attenuating astrogliosis and glial scar formation after ischemic injury.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | Kai Zhong et al. | 20 citations | 2020
Randomized Controlled Trial
Animal Trial
Rigorous Journal
Saffron: Chemical Composition and Neuroprotective Activity
Saffron's ability to cope with retinal neurodegeneration is related to the presence of specific crocins and the contribution of other saffron components.
Molecules | M. Maggi et al. | 30 citations | 2020
Systematic Review
Saffron pre-treatment offers neuroprotection to Nigral and retinal dopaminergic cells of MPTP-Treated mice.
Saffron pre-treatment saved many dopaminergic cells of the substantia nigra pars compacta (SNc) and retina from parkinsonian (MPTP) insult.
Journal of Parkinson's disease | Sivaraman Purushothuman et al. | 58 citations | 2013
Non Randomized Controlled Trial
Animal Trial
Rigorous Journal
Can Saffron Help Maintain Balanced Oxidation Levels?
Summary
We've highlighted the some of the relevant studies below.
Effects of saffron supplementation on oxidative/antioxidant status and severity of disease in ulcerative colitis patients: A randomized, double‐blind, placebo‐controlled study
Saffron supplementation significantly increased serum levels of total antioxidant capacity, superoxide dismutase, and glutathione peroxidase.
Phytotherapy Research | N. Tahvilian et al. | 18 citations | 2020
Randomized Controlled Trial
Effect of saffron supplementation on oxidative stress markers (MDA, TAC, TOS, GPx, SOD, and pro-oxidant/antioxidant balance): An updated systematic review and meta-analysis of randomized placebo-controlled trials
Saffron consumption significantly decreases MDA and TOS levels and increases TAC and GPx levels, helping maintain balanced oxidation levels.
Frontiers in Medicine | A. Abedi et al. | 3 citations | 2023
Meta Analysis
The effect of saffron (Crocus sativus L.) on glycemia, lipid profile, and antioxidant status in patients: A randomized placebo‐controlled trial
Saffron supplementation can improve oxidative status by reducing nitric oxide and malondialdehyde levels in patients.
Phytotherapy Research | A. Tajaddini et al. | 5 citations | 2022
Randomized Controlled Trial
The role of Safranal and saffron stigma extracts in oxidative stress and photoaging: A systematic review
Safranal, a major component of saffron, has immense antioxidant potential and is used as a therapeutic agent.
Heliyon | S. Nanda et al. | 28 citations | 2021
Systematic Review
Shop Saffron
Saffron Capsules
Buying supplements can be confusing, but it doesn't have to be.
Let us take the guess work out of analyzing the research, so you can be sure the benefits from the products you take are backed by valid science.
LEARN MORE BELOW
Saffron Primary Benefits
Mood
Neuroprotection
Cognition
Oxidation
The studies highlighted below are based on general research of Saffron, not specifically on Nootropics Depot's product. Saffron can come in many forms and standardizations, and not all of them have the same efficacy. This research snapshot is intended to highlight the current state of the science regarding Saffron, and should not be construed as direct evidence for the clinical efficacy of any one specific product.
Does Berberine Phytosome Support Lipid Metabolism?
Summary
We've highlighted the 4 most relevant studies below.
Tap Below To See Each Study
Affron® A Novel Saffron Extract Improves Mood
Affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized,
placebo-controlled clinical trial.
Complementary therapies in medicine | Graham Kell et al. | 60 citations | 2017
Randomized Controlled Trial
Effects Of Saffron Extract Supplementation On Mood
Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel Group, Clinical Trial
Frontiers in Nutrition | P. Jackson et al. | 22 citations | 2021
Randomized Controlled Trial
Saffron For Supporting Mental Well-Being
Saffron for supporting mental well-being: Current evidence and potential mechanisms of action.
Journal of affective disorders | Mojtaba Shafiee et al. | 107 citations | 2018
Rigorous Journal
Highly Cited
Affron® A Standardised Extract From Saffron For The Treatment Of Stress
Affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of stress: A randomised, double-blind, placebo-controlled study.
Journal of affective disorders | Adrian L. Lopresti et al. | 43 citations | 2018
Randomized Controlled Trial
Rigorous Journal
Does Saffron Improve Cognitive Function?
Summary
We've highlighted the 4 most relevant studies below.
Tap Below To See Each Study
Association Between Chronic Stress And Memory: Therapeutic Effects Of Saffron.
Association between chronic stress and memory: Therapeutic effects of Saffron.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | Mohammad Saeedi et al. | 34 citations | 2020
Systematic Review
Memory Enhancing Effects Of Saffron
Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection
FBehavioural Brain Research | Magdalini A. Papandreou et al. | 194 citations | 2011
Non Randomized Controlled Trial
Animal Trial
Highly Cited
Neuroprotective Effects Of Saffron
Neuroprotective effects of saffron on the late cerebral ischemia injury through inhibiting astrogliosis and glial scar formation in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | Kai Zhong et al. | 20 citations | 2020
Rigorous Journal
Highly Cited
Randomized Controlled Trial
Association Of Crocus Sativus With Cognitive Impairments and Cognitive Decline: A Systematic Review.
Association of Crocus sativus with Cognitive Impairments and Cognitive Decline: A Systematic Review.
Biointerface Research in Applied Chemistry | M. Talebi et al. | 13 Citations | 2020
Systematic Review
Can Saffron Offer Neuroprotection?
Summary
We've highlighted the 4 most relevant studies below.
Tap Below To See Each Study
Protective Properties Of The Aqueous Extract Of Saffron
Protective properties of the aqueous extract of saffron (Crocus sativus L.) randomized clinical trial.
Journal of Ethnopharmacology | Mostafa Asadollahi et al. | 19 citations | 2019
Randomized Controlled Trial
Neuroprotective Effects Of Saffron
Neuroprotective effects of saffron on the late cerebral ischemia injury through inhibiting astrogliosis and glial scar formation in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | Kai Zhong et al. | 20 citations | 2020
Randomized Controlled Trial
Animal Trial
Rigorous Journal
Saffron: Chemical Composition And Neuroprotective Activity
Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of β-amyloid in APP/tau/PS1 mouse model.
Molecules | M. Maggi et al. | 30 citations | 2020
Systematic Review
Saffron Pre-Treatment Offers Neuroprotection
Saffron pre-treatment offers neuroprotection to Nigral and retinal dopaminergic cells of MPTP-Treated mice.
Journal of Parkinson's disease | Sivaraman Purushothuman et al. | 58 citations | 2013
Non Randomized Controlled Trial
Animal Trial
Rigorous Journal
Can Saffron Help Maintain Balanced Oxidation Levels?
Summary
We've highlighted the 4 most relevant studies below.
Tap Below To See Each Study
Effects Of Saffron Supplementation On Oxidative/Antioxidant Status
Effects of saffron supplementation on oxidative/antioxidant status and severity of disease in ulcerative colitis patients: A randomized, double‐blind, placebo‐controlled study
Phytotherapy Research | N. Tahvilian et al. | 18 citations | 2020
Randomized Controlled Trial
Effect Of Saffron Supplementation On Oxidative Stress Markers
Effect of saffron supplementation on oxidative stress markers (MDA, TAC, TOS, GPx, SOD, and pro-oxidant/antioxidant balance): An updated systematic review and meta-analysis of randomized placebo-controlled trials
Frontiers in Medicine | A. Abedi et al. | 3 citations | 2023
Meta Analysis
The Effect Of Saffron On Glycemia, Lipid Profile, And Antioxidant Status In Patients: A Randomized Placebo‐Controlled Trial
The effect of saffron (Crocus sativus L.) on glycemia, lipid profile, and antioxidant status in patients: A randomized placebo‐controlled trial
Phytotherapy Research | A. Tajaddini et al. | 5 citations | 2022
Randomized Controlled Trial
The Role Of Safranal And Saffron Stigma Extracts
The role of Safranal and saffron stigma extracts in oxidative stress and photoaging: A systematic review
Heliyon | S. Nanda et al. | 28 citations | 2021
Systematic Review