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Horny Goat Weed Capsules | 50% Icariin

Standardized to minimum 50% icariin for blood flow, cardiovascular health, libido, and vitality support.

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Horny Goat Weed Capsules | 50% Icariin

Standardized to minimum 50% icariin for blood flow, cardiovascular health, libido, and vitality support.

(4 Reviews) Write a Review

View All Reviews

Available in multiple forms! Click Here for:
  • 50% Icariin Standardization Guaranteed
  • Natural PDE-5 Inhibitor For Blood Flow
  • Supports Testosterone Levels Naturally
  • Third-Party Lab Tested Purity

3rd Party Lab Tested & Verified

See Why ND Horny Goat Is The Best

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Updated On: 05/23/2026

$29.99

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Benefits

When You'll Notice Effects

2-3 Weeks (With Immediate Effects)

  • Bone Health
  • Cardiovascular
  • Neuroprotection
  • Blood Flow

Why ND Horny Goat Weed?

A Horny Goat Weed standardized to 50% icariin
test

How To Take

Dose
Dose

One Capsule

Timing
Timing

Flexible

How to Take
How to Take

With Or Without Food

Frequency
Frequency

1 Time Daily

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  • About Horny Goat Weed Capsules

    Our Horny Goat Weed Extract delivers 50% icariin from Epimedium brevicornum, providing targeted support for blood flow and cardiovascular function. This concentrated extract supports healthy circulation while supporting testosterone levels and overall vitality.

    Our Horny Goat Weed Story

    We developed this highly concentrated 50% icariin extract to address a specific gap in the market. Most horny goat weed supplements provide low-potency extracts with minimal standardization, so we created a targeted formula that maximizes icariin's blood flow benefits without the complex array of secondary compounds that can muddy the experience.

    Extensive beta-testing revealed that concentrating icariin to 50% produces a remarkably "clean" effect profile compared to lower-concentration extracts. Concentrating icariin allows us to harness its blood flow support mechanism, delivering consistent circulation support that makes an excellent addition to various supplement stacks or as a standalone daily supplement for those seeking targeted cardiovascular benefits.

    Benefits

    • Promotes Bone Health: Icariin supports bone strength and density by promoting osteoblast activity and helping maintain healthy calcium levels within bone tissue.
    • Promotes Cardiovascular Function: The 50% icariin extract supports heart health by promoting healthy circulation and helping maintain blood pressure levels already within the normal range.
    • Supports Healthy Neurological Function: Icariin supports nerve cell health and healthy neural function, contributing to cognitive health and mental clarity.
    • Supports Blood Flow: This compound promotes enhanced blood flow, particularly to peripheral tissues, supporting healthy circulation and physical performance.

    Horny goat weed also supports healthy hormone balance by supporting healthy testosterone levels in both men and women. This hormonal support contributes to improved mood, energy levels, and overall sense of wellbeing, making it a valuable addition to any vitality-focused supplement regimen.

    Quality and Standardization

    • Standardized Extraction: Our Horny Goat Weed Extract is precisely standardized to contain a minimum of 50% icariin by HPLC, ensuring consistent potency and reliable bioactive compound delivery in every capsule.
    • Selective Concentration Process: We employ advanced extraction techniques to concentrate icariin to 50%, creating a cleaner, more targeted supplement compared to lower-concentration extracts that contain numerous auxiliary compounds.
    • Third-Party Verification: Every batch undergoes comprehensive third-party testing for identity confirmation, purity verification, and potency validation to ensure pharmaceutical-grade quality standards.
    • Premium Raw Material Sourcing: We source high-quality Epimedium brevicornum aerial parts and process them using controlled extraction parameters to maintain the integrity of the active flavonoid compounds.

    Mechanism of Action

    • PDE-5 Enzyme Activity: Icariin supports phosphodiesterase-5 activity, supporting cyclic guanosine monophosphate (cGMP) levels in smooth muscle tissue. This supports vasodilation and enhanced blood flow throughout the circulatory system.
    • Testosterone Signaling Support: The flavonoid works through multiple pathways to support healthy testosterone production, including effects on luteinizing hormone signaling and testicular steroidogenesis pathways that support androgen synthesis.
    • Nitric Oxide Pathway Enhancement: Icariin promotes nitric oxide bioavailability by supporting endothelial nitric oxide synthase (eNOS) activity, which contributes to improved vascular function and healthy circulation patterns.
    • Calcium Channel Support: The compound supports calcium ion channels in vascular smooth muscle, helping support muscle function cycles that are essential for optimal blood vessel function and tissue perfusion.

    Horny Goat Weed Mechanism of Action Diagram

    Overview of the Science

    Research demonstrates that icariin functions as a selective phosphodiesterase-5 (PDE-5) inhibitor, with studies showing significant enzyme inhibition activity [1]. This selective inhibition mechanism promotes enhanced circulation by preventing the breakdown of cyclic guanosine monophosphate (cGMP), a crucial signaling molecule that regulates smooth muscle relaxation in blood vessels [2]. Additionally, research indicates that icariin supports healthy testosterone levels through its effects on steroidogenesis, with animal studies demonstrating increased testosterone production following supplementation [3][4].

    Clinical investigations have revealed that icariin supports protective effects on cardiovascular tissue, particularly through its antioxidant activity and support for endothelial function [5]. Research suggests that icariin supports protection against oxidative damage to blood vessels while promoting healthy nitric oxide signaling pathways [6]. Studies also indicate that the compound supports sexual function through multiple mechanisms, including enhanced penile tissue strength and improved blood flow dynamics via the PI3K/AKT/eNOS pathway [7].

    [1] Xin ZC, Kim EK, Tian ZJ, Lin GT, Guo YL. Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. BJU Int. 2003;92:631-5.

    [2] Shindel AW, Xin ZC, Lin G, Fandel TM, Huang YC, Banie L, Breyer BN, Garcia MM, Lin CS, Lue TF. Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo. J Sex Med. 2010;7:1518-1528.

    [3] Zhang ZB, Yang QT. The testosterone mimetic properties of icariin. Asian J Androl. 2006;8:601-5.

    [4] Chen M, Hao J, Yang Q, Li G. Effects of icariin on reproductive functions in male rats. Molecules. 2014;19:9502-9514.

    [5] Wang YK, Huang ZQ. Protective effects of icariin on human umbilical vein endothelial cell injury induced by H2O2 in vitro. Pharmacol Res. 2005;52:174-82.

    [6] Zhai M, He L, Ju X, Li G, Zhang Y, Liu Y, Zhao H. Icariin acts as a potential agent for preventing cardiac ischemia/reperfusion injury. Cell Biochem Biophys. 2015;72:589-597.

    [7] Xu SB, Zhang YQ, Lian DJ, Wang YJ, Chen XM. Icariin improves the sexual function of male mice through the PI3K/AKT/eNOS/NO signalling pathway. Andrologia. 2018;50:e12802.


    Click here to read the Research Snapshot

    Ingredients

    Horny Goat Weed Extract:

    • Epimedium brevicornum aerial parts extract
    • Standardized to minimum 50% icariin by HPLC
    • 200mg per capsule

    This highly concentrated 50% icariin standardization represents a significant potency advancement over standard horny goat weed extracts. The HPLC standardization ensures precise measurement of the primary bioactive compound responsible for horny goat weed's effects on blood circulation and vitality supplements. The concentrated nature of this extract delivers more targeted effects compared to lower-potency extracts, providing reliable dosing of the key flavonoid compound that drives horny goat weed's bone health supplements and cardiovascular support properties.

    Horny Goat Weed supplement facts panel showing 200mg per capsule standardized to minimum 50% icariin

  • Frequently asked questions

    1. How does 50% icariin work for blood flow?

      Icariin works as a selective PDE-5 inhibitor, preventing the breakdown of cyclic guanosine monophosphate (cGMP) which regulates smooth muscle relaxation in blood vessels. This mechanism promotes enhanced circulation by allowing blood vessels to remain dilated and maintain healthy blood flow. Our 50% icariin extract provides a concentrated dose of this active compound to support cardiovascular function and circulation.

    2. Why choose Nootropics Depot's 50% icariin extract?

      Our Horny Goat Weed extract delivers a highly concentrated 50% icariin standardization from Epimedium brevicornum, significantly higher than most low-potency extracts on the market. This concentrated formula maximizes icariin's blood flow benefits through selective PDE-5 inhibition, supporting cardiovascular function and healthy circulation. We created this targeted extract to address the gap in standardized horny goat weed supplements, providing consistent potency with every batch.

    3. How long does Icariin stay in your system?

      Icariin has a relatively short half-life and is typically cleared from the system within 24-48 hours after ingestion. Our Horny Goat Weed extract with 50% icariin is designed for daily use, with effects building over 2-3 weeks of consistent supplementation while some immediate effects may be noticed. For sustained benefits, regular daily dosing is recommended rather than relying on single-dose accumulation.

    4. What is Icariin?

      Icariin is the primary active compound found in horny goat weed (Epimedium brevicornum) that acts as a selective PDE-5 inhibitor to support healthy blood flow and circulation. This flavonoid compound promotes cardiovascular function by preventing the breakdown of cGMP, a signaling molecule that helps regulate smooth muscle relaxation in blood vessels. Our Horny Goat Weed extract is standardized to deliver a minimum of 50% icariin for consistent potency and targeted support.

    5. How much icariin should I take daily?

      Our Horny Goat Weed capsules provide 200mg per serving with a minimum 50% icariin standardization, delivering at least 100mg of active icariin daily. We recommend taking one capsule daily, which can be taken with or without food. This dosage is designed to support blood flow and cardiovascular function while providing the selective PDE-5 inhibition benefits that icariin is known for.

    6. Can I stack icariin with testosterone boosters?

      Yes, our 50% icariin extract can be stacked with testosterone boosters since it works through a different mechanism as a selective PDE-5 inhibitor while also supporting healthy testosterone levels. The icariin promotes cardiovascular function and blood flow, which can complement the effects of testosterone-supporting supplements. We recommend starting with standard doses of each and monitoring how you respond to the combination.

    7. Why did Nootropics Depot choose 50% icariin concentration?

      We chose 50% icariin concentration to address a specific gap in the market where most horny goat weed supplements provide low-potency extracts with minimal standardization. This highly concentrated extract maximizes icariin's blood flow benefits as a selective PDE-5 inhibitor, delivering targeted support for cardiovascular function and circulation. Our 50% standardization ensures consistent potency and reliable effects compared to unstandardized alternatives.

    8. Can I take icariin with Boron supplements?

      Yes, icariin and boron can be taken together as they work through different pathways and don't have known interactions. Our 50% Icariin extract supports cardiovascular function and blood flow through PDE-5 inhibition, while boron typically supports hormone balance and bone health. Both supplements can be taken with or without food according to your preference.

The Science

What Our Scientific Board Does

The Process

What Do They Do?

  • Review Product Claims
  • Review Cited Research
  • Suggest Changes to Claims
  • Approves Final Conclusions
See The Process

Overview Of The Scientific Evidence

Our Research Snapshot

What Does The Research Show?

Available scientific research shows that Horny Goat Weed, via its bioactive icariin, may support blood flow, sexual function, libido, mood, and stress resilience

Understand The Evidence

Trust Through Transparency

Your health matters, which is why we only use the best 3rd party ISO accredited labs and cGMP certified and FDA registered facilities right here in the USA

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Horny Goat Weed Capsules | 50% Icariin

Horny Goat Weed Capsules | 50% Icariin

$29.99