About Oleamide Powder

Oleamide is a naturally occurring fatty acid amide derived from oleic acid, an omega-9 fatty acid found in olive oil. This colorless, waxy compound was first discovered in the cerebrospinal fluid of sleep-deprived cats and naturally accumulates in human cerebrospinal fluid during periods of sleep deprivation. Oleamide supports healthy sleep patterns while promoting cognitive function and brain health through its interactions with multiple neurotransmitter systems.

Our Oleamide Story

The discovery of oleamide in sleep-deprived animals sparked our interest in this unique compound. Oleamide has been present in traditional Chinese practices for over 2,500 years through jujube fruit, yet the scientific understanding of its mechanisms remained incomplete. We recognized the need for a pure, research-grade oleamide supplement that could deliver consistent results for those seeking natural Sleep support.

Our oleamide powder provides the pure compound without the variability of plant extracts. We source high-quality oleamide that undergoes rigorous testing for purity and identity, ensuring you receive exactly what's on the label. Researchers and supplement users gain access to the same compound that occurs naturally in the human body, allowing for precise dosing and reliable support for healthy sleep cycles and cognitive function.

Benefits

• Supports Healthy Sleep Habits & Relaxation: Oleamide interacts with GABA receptors in the brain, promoting natural relaxation and supporting your body's sleep-wake cycle.
• Supports Short-Term & Working Memory: Research shows oleamide enhances 5-HT2A serotonin receptor sensitivity without disrupting normal signaling, supporting cognitive processing and memory function.
• Promotes Feelings Of Calm And Well-Being: By binding to CB1 receptors and modulating serotonin pathways, oleamide helps promote balanced mood and emotional stability.
• Supports Healthy Neuronal Function: Oleamide acts on multiple neurotransmitter systems including 5-HT1A and 5-HT2C receptors, supporting overall brain health and cellular function.

Oleamide's sleep benefits come with unique dual-action properties at 5-HT7 receptors, functioning as both an inhibitor when serotonin is present and an agonist when serotonin levels are low. This adaptive mechanism maintains balanced neurotransmitter activity across varying physiological states, supporting consistent cognitive performance throughout the day.

Quality and Standardization

• Third-Party Lab Verified Purity: We test our oleamide powder through third-party labs to verify both product purity and identity, ensuring you receive a clean, potent compound free from contaminants.
• High-Grade Fatty Acid Amide Source: Our oleamide is sourced as a pure fatty acid primary amide (FAPA) that maintains the same molecular structure found naturally in human cerebrospinal fluid.
• Precise 100mg Dosing Protocol: Each serving delivers exactly 100mg of oleamide, allowing for consistent dosing that aligns with research protocols and supports reliable effects.
• Standardized Manufacturing Process: Produced in cGMP-certified facilities using standardized extraction and purification methods to maintain consistent potency and quality across every batch.

Mechanism of Action

• GABA Receptor Modulation: Oleamide binds to GABA receptors in the brain, enhancing the activity of this primary inhibitory neurotransmitter system to promote natural relaxation and support healthy sleep initiation.
• Cannabinoid Receptor Interaction: This fatty acid amide activates both CB1 and CB2 cannabinoid receptors, with CB1 binding supporting neuronal communication and CB2 activation helping maintain a healthy response in neural tissue.
• Serotonin Receptor Enhancement: Oleamide increases the sensitivity of 5-HT2A, 5-HT1A, and 5-HT2C serotonin receptors without altering normal serotonin binding, while also acting as a 5-HT7 receptor antagonist to modulate circadian rhythm signaling.
• Endogenous Sleep Signal: As cerebrospinal fluid levels naturally rise during sleep deprivation, oleamide functions as part of the body's homeostatic sleep drive mechanism, accumulating to signal the need for restorative rest and supporting healthy neurotransmitter balance.

Overview of the Science

Research suggests oleamide demonstrates complex interactions with multiple neurotransmitter systems beyond its GABA receptor activity [1]. Studies indicate this fatty acid amide enhances the sensitivity of 5-HT2A serotonin receptors without disrupting normal signaling pathways, while also extending this enhanced sensitivity to 5-HT1A and 5-HT2C receptor subtypes. Notably, oleamide binds to 5-HT7 receptors and acts as an inhibitor, functioning as an agonist when serotonin is absent and producing serotonin-like effects at lower intensities.

The compound's structural similarity to anandamide explains its ability to interact with cannabinoid receptors, particularly CB1 and CB2 subtypes. This interaction suggests oleamide supports healthy cellular function and balanced stress responses through endocannabinoid system modulation. Traditional Chinese practices have utilized Adaptogens like jujube fruit for sleep support for over 2,500 years, long before scientists discovered that oleamide naturally occurs in these plants and is synthesized in humans from ammonia and oleic acid.

[1] Verdon B et al. Br J Pharmacol. 2000;129(2):283-90.

Ingredients

Oleamide:

• Pure oleamide powder
• 100mg per serving
• Fatty acid primary amide (FAPA)

Our oleamide powder delivers 100mg of pure fatty acid primary amide per serving, providing the exact dosage used in sleep and cognitive research studies. This standardized amount ensures consistent potency while maintaining the compound's natural waxy texture and colorless appearance that characterizes authentic oleamide. The precise 100mg serving size reflects optimal bioavailability for GABA supplements for sleep support and cognitive enhancement protocols.