About OptiNAD+ Capsules
OptiNAD+ combines six carefully selected ingredients to boost nicotinamide adenine dinucleotide (NAD+) levels throughout your body. The formula features NMN supplements and nicotinamide riboside alongside NADH, plus synergistic compounds like apigenin and quercetin that help preserve and optimize the NAD+ you produce. OptiNAD+ supports cellular health supplements by enhancing mitochondrial energy production and promoting healthy aging processes.
Our OptiNAD+ Story
Most NAD+ supplements on the market take a single-ingredient approach, typically offering just NMN or nicotinamide riboside alone. While these individual precursors have merit, we knew there was potential for a more sophisticated strategy. Even high doses of standalone NAD+ precursors often fell short of their potential because they lacked the supporting compounds needed to optimize bioavailability and prevent breakdown.
We created the first truly comprehensive NAD+ enhancement stack by combining multiple complementary NAD+ precursors working through different pathways, then adding protective compounds like apigenin and quercetin to inhibit CD38 (the enzyme that degrades NAD+), plus trimethylglycine to replenish the methyl groups consumed during NAD+ synthesis. After extensive beta testing with our team, we achieved what we consider the most effective NAD+ enhancement formula available. The difference is immediately noticeable compared to single-ingredient alternatives.
Benefits
- Enhances Mitochondrial Function: OptiNAD+ supports the powerhouses of your cells by providing multiple NAD+ precursors that fuel mitochondrial energy production and ATP synthesis.
- Enhances Cellular Energy: The combination of nicotinamide mononucleotide, nicotinamide riboside, and NADH creates a noticeable increase in physical and mental vitality that users describe as having more juice in their batteries.
- Supports Longevity and Healthspan: By maintaining optimal NAD+ levels that naturally decline with age, this formula activates sirtuins and supports the cellular processes associated with longevity and healthy aging.
- Helps Regulate Circadian Rhythms: NAD+ plays a crucial role in your body's internal clock, and users often experience progressively better sleep quality as their circadian rhythms become more synchronized.
The apigenin and quercetin in this formula inhibit CD38, an enzyme that breaks down NAD+, while quercetin upregulates sirtuin activity to maximize the NAD+ benefits you experience from each dose.
Quality and Standardization
- Multi-pathway NAD+ enhancement: Our comprehensive formulation combines three distinct NAD+ precursors (NMN, nicotinamide riboside, and NADH) with CD38 inhibitors (apigenin and quercetin) to maximize bioavailability and retention of NAD+ levels throughout the body.
- Standardized ingredient potency: Each capsule delivers precise amounts of pharmaceutical-grade compounds, ensuring consistent NAD+ support with every dose while maintaining optimal ratios between precursors and synergistic enhancers.
- Methyl group replenishment: We included trimethylglycine as a highly efficient methyl donor to counteract the methyl group depletion that occurs during intensive NAD+ synthesis, supporting sustained cellular health processes.
- Third-party verified purity: All components undergo rigorous testing for identity, potency, and contaminants to ensure you receive the cleanest, most effective NAD+ enhancement formula available.
Mechanism of Action
- NAD+ Salvage Pathway Activation: Nicotinamide mononucleotide bypasses rate-limiting enzymes to directly enter cells via specialized Slc12a8 transporters, while nicotinamide riboside activates the NRK1/NRK2 kinase pathway for efficient NAD+ synthesis.
- CD38 Enzyme Inhibition: Apigenin and quercetin competitively block CD38 NADase activity, preventing the enzymatic degradation that normally consumes up to 95% of cellular NAD+ in aging tissues.
- Direct NADH Transport: NADH utilizes specialized mitochondrial shuttles and cytoplasmic reductase systems to rapidly convert to NAD+ while simultaneously supporting electron transport chain efficiency.
- Sirtuin Pathway Enhancement: Quercetin upregulates SIRT1 and SIRT3 expression through FOXO transcription factor activation, creating increased demand for NAD+ as substrate while supporting cellular stress resistance and metabolic optimization.
- Methyl Group Replenishment: Trimethylglycine supplies methyl donors through the betaine-homocysteine methyltransferase pathway, preventing S-adenosylmethionine depletion that occurs during intensive NAD+ biosynthesis and supporting optimal methylation reactions.
Overview of the Science
Clinical trials demonstrate that NAD+ supplementation can significantly elevate circulating NAD+ levels in healthy adults [1][2]. Studies show that nicotinamide mononucleotide supplementation increases blood NAD+ concentrations by up to 1.7-fold within 12 weeks, with benefits observed for muscle function and arterial health [3][4]. Nicotinamide riboside has been shown to safely raise NAD+ levels by 40-90% in healthy middle-aged and older adults, with sustained elevation throughout chronic supplementation periods [5][6][7]. Research indicates that combining multiple NAD+ precursors with CD38 inhibitors may enhance bioavailability and retention compared to single-ingredient approaches [8].
The circadian regulation of NAD+ synthesis represents a critical factor in optimizing supplementation timing and efficacy. NAD+ levels naturally fluctuate throughout the day, with peak synthesis occurring during morning hours when energy demands are highest. This rhythmic pattern suggests that morning administration of NAD+ precursors may align with endogenous biosynthetic pathways for maximum utilization. Additionally, caloric restriction and fasting states have been shown to upregulate NAD+ synthetic enzymes, indicating that supplementation during periods of metabolic stress or alongside metabolism support protocols may enhance overall effectiveness.
[1] Igarashi M et al. Scientific Reports. 2023;13(1):2994.
[2] Pencina K et al. GeroScience. 2022;45(3):1631-1648.
[3] Ito K et al. Frontiers in Aging. 2022;3:870640.
[4] Fukamizu Y et al. npj Aging. 2022;8(1):5.
[5] Campbell JM et al. GeroScience. 2024;46(1):665-685.
[6] Dellinger RW et al. npj Aging and Mechanisms of Disease. 2017;3(1):17.
[7] Martens CR et al. Nature Communications. 2018;9(1):1286.
[8] Perez KN et al. Nature Communications. 2023;14(1):8050.
Ingredients
- High-efficiency methyl donor that supports healthy homocysteine metabolism and NAD⁺ synthesis
- Ingredient source: Trimethylglycine (as betaine HCl)
- Amount per serving: 500 mg
- Primary benefit: Replenishes methyl groups consumed during intensive NAD⁺ production to maintain metabolic balance
- Dual‑action flavonoid that helps inhibit CD38 while supporting sirtuin activity
- Ingredient source: Quercetin (95% anhydrous extract)
- Amount per serving: 250 mg
- Primary benefit: Helps preserve NAD⁺ levels and supports longevity-related sirtuin pathways
- Direct NAD⁺ precursor requiring only one enzymatic conversion step in the salvage pathway
- Ingredient source: Nicotinamide mononucleotide
- Amount per serving: 200 mg
- Primary benefit: Supports rapid NAD⁺ generation for cellular energy and mitochondrial function
- Alternative NAD⁺ precursor that enters the NAD⁺ salvage pathway through NRK enzymes
- Ingredient source: Nicotinamide riboside chloride
- Amount per serving: 200 mg
- Primary benefit: Provides complementary NAD⁺ support with a focus on neuronal health and resilience
- Flavone that helps inhibit CD38, a key NAD⁺-consuming enzyme
- Ingredient source: Apigenin (98% extract)
- Amount per serving: 50 mg
- Primary benefit: Helps preserve existing NAD⁺ pools to maximize the impact of supplemented precursors
- Reduced form of NAD⁺ that feeds directly into mitochondrial ATP production
- Ingredient source: Reduced nicotinamide adenine dinucleotide (NADH)
- Amount per serving: 10 mg
- Primary benefit: Provides immediate support for cellular energy generation and redox balance
Mitochondria
Physical Energy
Longevity
Sleep
