Piprine is derived from peppercorns from the Piper nigrum, a plant that flowers peppercorns. The unripe peppercorns are dried and cooked to make black pepper. Piperine is the primary bioactive component in black pepper.
Piperine is most commonly used to enhance bioavailability of other supplements, most famously, curcumin. Research has found that a piperine supplement may increase the bioavailability of curcumin by as much as 2000% from baseline levels. Piperine is able to achieve this by inhibiting or downregulating inhibiting phase II detoxification enzymes as well as the glucuronidation process in the liver. Glucuronidation attaches a glucuronide molecule to compounds so that they can be excreted through the urine. Piperine inhibits this process which may lead to elevated levels of certain compounds in the blood.
By inhibiting the detoxifying enzymes, the bioavailability of compounds already in the system is increased. Piperine may slow intestinal transit rate which can increase overall absorption. This may prolong the time compounds are exposed to potential uptake. Piperine also prevents Monoamine oxidase from removing neurotransmitters from the brain, leaving these neurotransmitters open to stimulate brain cells.
Piperine is naturally found in the Piper Nigrum plant which produces white and black pepper. Black pepper carries the bioactive compound known as piperine, which is also responsible for black pepper’s distinct taste. Piperine is sometimes referred to as pepperine or black pepper extract.
Black pepper has been traditionally used to support gastrointestinal comfort. Piperine is believed to be responsible for black pepper’s properties in supporting gastrointestinal comfort.
Some studies have found that a piperine supplement may slow down both gastric emptying and intestinal transit in low doses and may induce gastric acid secretion in higher doses. Due to its nature to limit glucuronidation, Piperine is great to pair with Curcumin. Piperine also supports general metabolic health in addition to promoting the absorption of other supplements. Clinical research of piperine in humans is limited, however it's been widely noted that piperine’s primary function is to increase the bioavailability of other compounds in the body.
As a dietary supplement, take 1 Piperine capsule 1-2 times daily, preferably with a meal.
To gain more insight, see the Piperine reviews and experiences below.
Nootropics Depot offers 60 count or 120 count jars of high quality Piperine capsules. Nootropics Depot’s Piperine has been lab-tested and verified for both product purity and identity.
You may like to pair Piperine capsules with Curcumin powder.
Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.