About Pomella Powder

Pomella is a clinically researched pomegranate extract standardized to punicalagins, the bioactive compounds that provide superior absorption compared to isolated ellagic acid. This whole-fruit extract supports healthy cardiovascular function and promotes a balanced inflammatory response while delivering the antioxidant potency of several pomegranates in a concentrated dose.

Our Pomella Story

The pomegranate extract market was flooded with products focused on isolated ellagic acid, despite research showing poor bioavailability for this compound. We recognized that the whole-fruit polyphenol profile, particularly punicalagins, unlocks pomegranate's true potential. This insight led us to source Pomella, an extract that preserves the native ratio of pomegranate compounds rather than chasing single isolated actives.

Our Pomella powder maintains the complete spectrum of bioactive punicalagins that metabolize into beneficial compounds like urolithin A and other metabolites linked to longevity support. Backed by over 30 clinical trials and proven superior absorption in Texas A&M research, Pomella represents what pomegranate supplementation should be: scientifically validated, bioavailable, and true to the fruit's natural composition.

Benefits

• Supports Healthy Cardiovascular Function: Pomella provides punicalagins that benefit markers of cardiovascular health, with over 30 clinical trials demonstrating its effects on vascular function and heart health support.
• Supports Cellular Antioxidant Activity: The extract increases plasma levels of bioactive metabolites including urolithin B, hydroxyl-urolithin A, and dimethyl ellagic acid-glucuronide, compounds that provide potent oxidation balancing activity to protect cells from daily oxidative challenges.
• Supports Healthy Inflammatory Response: Punicalagins from pomegranate help maintain balanced inflammatory processes throughout the body, supporting the natural resolution of inflammation and promoting healthy tissue function.
• Supports Healthy Cellular Aging: Pomella promotes longevity pathways by delivering metabolites that support cellular health and help maintain youthful cellular function over time.

The superior bioavailability of Pomella sets it apart from isolated compounds, as research from Texas A&M University shows that punicalagins absorb into colon cells as bioactive metabolites while purified ellagic acid does not absorb at all. The whole-fruit approach preserves the native ratio of pomegranate polyphenols, delivering the equivalent antioxidant power of several pomegranates in each clinically researched dose.

Quality and Standardization

• Punicalagin Standardization: Our Pomella extract is precisely standardized to punicalagins, the key bioactive compounds that distinguish it from generic pomegranate extracts containing only ellagic acid.
• Clinical Research Validation: Pomella has undergone extensive human clinical research with over 30 clinical trials demonstrating its bioavailability and health benefits in real-world applications.
• Superior Absorption Profile: Texas A&M University research confirmed that Pomella absorbs into colon cells as bioactive metabolites, while purified ellagic acid showed no absorption, proving the importance of whole-fruit pomegranate polyphenol preservation.
• Third-Party Verified Quality: Every batch undergoes rigorous testing at our third-party labs to verify both product purity and identity, ensuring consistent potency and quality.

Mechanism of Action

• Punicalagin Absorption and Metabolism: Pomella's punicalagins are absorbed into colon cells as bioactive metabolites, where they undergo bacterial fermentation to produce beneficial compounds like urolithin A and ellagic acid derivatives that support cellular health throughout the body.
• Gut Microbiome Conversion: The extract's polyphenolic compounds are metabolized by beneficial gut bacteria into bioavailable metabolites that cross the intestinal barrier more effectively than isolated ellagic acid, explaining the superior bioactivity observed in clinical studies.
• Vascular Endothelial Support: Pomella's punicalagins help maintain healthy endothelial function by supporting nitric oxide production and promoting optimal blood vessel flexibility, contributing to overall cardiovascular wellness.
• Antioxidant Enzyme Activation: The extract supports the body's natural antioxidant defense systems by promoting the activity of endogenous enzymes like superoxide dismutase and catalase, which help maintain cellular protection against oxidative stress.

Overview of the Science

Clinical studies demonstrate that Pomella's punicalagins promote significant improvements in multiple cardiovascular biomarkers in healthy adults. Research published in Nutrients shows that pomegranate extract supplementation supports healthy inflammatory markers and cardiometabolic risk factors in adults aged 55-70 years [1]. A double-blind placebo-controlled trial found that participants consuming pomegranate extract experienced beneficial effects on blood pressure and anthropometric measurements compared to placebo [2]. The comprehensive metabolic benefits extend beyond basic Cardiovascular support, with systematic reviews confirming therapeutic effects across multiple health applications [3].

The extract's unique ability to modulate oxidative stress pathways has been validated in controlled clinical research. Studies in overweight individuals demonstrate that pomegranate extract supplementation supports healthy inflammatory responses through measurable reductions in inflammatory biomarkers [4]. Research on punicalagin metabolism reveals that these compounds enhance cardiac mitochondrial function through AMPK activation pathways [6]. Clinical trials also confirm that pomegranate consumption supports healthy serum profiles and cellular antioxidant activity in participants with metabolic concerns [7]. The metabolite urolithin A, produced from punicalagin breakdown, demonstrates significant individual variation in production based on gut microbiome composition, which explains differences in Anti Oxidative Stress Supplements effectiveness between users [8].

[1] Stockton A, McDougall GJ, Caruso M, Elharouni D, Jaramillo AM, Al-Dujaili EA. Effects of Pomegranate Extract on Inflammatory Markers and Cardiometabolic Risk Factors in Adults Aged 55–70 Years: A Randomised Controlled Parallel Trial. Nutrients. 2025;17(5):1235.

[2] Stockton A, Al-Dujaili EA, McDougall GJ, Drummond S, Caruso M. Effect of pomegranate extract on blood pressure and anthropometry in adults: a double-blind placebo-controlled randomised clinical trial. British Journal of Nutrition. 2017;118:1313-1322.

[3] Eghbali S, Askari SF, Avan R, Sahebkar A. Therapeutic Effects of Punica granatum (Pomegranate): An Updated Review of Clinical Trials. Journal of Nutrition and Metabolism. 2021;2021:5297162.

[4] Hosseini B, Saedisomeolia A, Wood LG, Yaseri M, Tavasoli S. Effects of pomegranate extract supplementation on inflammation in overweight and obese individuals: A randomized controlled clinical trial. Complementary Therapies in Clinical Practice. 2016;22:44-50.

[6] Zou X, Yan C, Shi Y, Cao K, Xu J, Wang X, Chen C, Luo C, Li Y, Gao J, et al. Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation. American Journal of Physiology-Endocrinology and Metabolism. 2014;306(4):E363-372.

[7] Rosenblat M, Hayek T, Aviram M. Anti-oxidative effects of pomegranate juice consumption by diabetic patients on serum and on macrophages. Atherosclerosis. 2006;187:363-371.

[8] González-Sarrías A, García-Villalba R, Romo-Vaquero M, Alasalvar C, Örem A, Zafrilla P, Tomás-Barberán FA, Selma MV, Espín JC. Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight-obese individuals consuming pomegranate: a randomized clinical trial. Molecular Nutrition and Food Research. 2017;61(5):1600830.

Ingredients

Pomella Natural Pomegranate Extract:

• Punica granatum L. (fruit) extract
• Standardized to 30% punicalagins by HPLC
• 150mg per serving

The 30% punicalagin standardization sets this extract apart from generic pomegranate powders that rely solely on ellagic acid content. This specific concentration ensures optimal bioavailability while preserving the full spectrum of native polyphenols found in whole pomegranate fruit. Research from Texas A&M University confirms that this standardized punicalagin content allows for superior absorption into colon cells, where bacterial metabolism converts these compounds into highly bioactive urolithin metabolites that support cellular health throughout the body.