About Sesame Extract Capsules

Sesame Extract provides a concentrated source of lignans, standardized to 70% sesamins, from one of humanity's oldest cultivated oil-rich seeds. This potent extract supports Metabolism, promotes healthy inflammation levels, and helps maintain balanced oxidation processes throughout your body.

Our Sesame Extract Story

Most sesame supplements offer crude seed powders or poorly standardized extracts with inconsistent lignan content. Despite sesamin being one of the most researched lignans for metabolic and cognitive support, consumers had limited access to properly concentrated extracts that delivered meaningful amounts of these bioactive compounds.

Our Sesame Extract delivers a consistent 70% sesamin content, ensuring each capsule provides substantial amounts of the primary lignan responsible for sesame's health benefits. Our standardized approach focuses on sesamin because research shows it regulates delta-5-desaturase enzyme activity and supports vitamin E metabolism better than other sesame lignans, making it the most valuable compound to concentrate and standardize.

Benefits

• Supports Healthy Fat Loss & Metabolism: Sesamin regulates delta-5-desaturase enzyme activity, which controls fatty acid metabolism and helps reduce arachidonic acid levels in the body.
• Promotes Healthy Cardiovascular Function: The lignan compounds in sesame extract support healthy blood lipid profiles and help maintain optimal cardiovascular function through balanced oxidation processes.
• Supports Balanced Oxidation Levels: Sesamin enhances vitamin E retention by regulating tocopherol-omega-hydroxylation, the rate-limiting step in vitamin E metabolism, leading to increased antioxidant protection.
• Supports Healthy Cognitive Function: Animal studies show sesamin promotes neuroprotection and supports healthy brain function through balanced inflammation responses and enhanced cellular protection mechanisms.

Sesame extract works with your body's natural antioxidant systems. By modulating key enzymatic pathways, this 70% sesamin standardized extract helps optimize your cellular defense mechanisms while supporting healthy inflammatory responses throughout multiple organ systems.

Quality and Standardization

• 70% Sesamin Standardization: Our sesame extract is standardized to contain a minimum of 70% sesamins, ensuring consistent potency and bioactivity in every capsule.
• Lab-Tested Purity: Each batch undergoes comprehensive testing for product purity and identity verification at our third-party labs to guarantee quality and safety.
• High-Concentration Lignans: We concentrate the most bioactive lignan compounds from sesame seeds, including sesamin, sesamolin, and sesaminol, for maximum therapeutic potential.
• Optimal Extraction Process: Our extraction method preserves the delicate lignan profile while achieving pharmaceutical-grade concentration standards for superior bioavailability.
• cGMP Manufacturing: Produced in FDA-registered, cGMP-certified facilities using stringent quality control protocols to ensure consistent anti oxidative stress supplements potency.

Mechanism of Action

• Delta-5-Desaturase Enzyme Regulation: Sesamin modulates delta-5-desaturase activity, the rate-limiting enzyme in arachidonic acid synthesis, which helps regulate fatty acid metabolism and supports Pain and Inflammation balance throughout the body.
• Vitamin E Metabolism Enhancement: The lignan compounds inhibit tocopherol-omega-hydroxylation, the rate-determining step in vitamin E breakdown, effectively increasing vitamin E bioavailability and extending its antioxidant activity in tissues.
• Neuroprotective Pathway Activation: Sesamin crosses the blood-brain barrier and activates cellular protective mechanisms in neural tissue, supporting healthy brain function through multiple pathways including mitochondrial protection and oxidative stress defense.
• Lignan Conversion and Bioactivity: Once absorbed, sesamin undergoes hepatic metabolism to produce active metabolites like enterolactone, which interact with cellular receptors to influence gene expression related to Longevity and metabolic health.

Overview of the Science

Sesame extract demonstrates remarkable neuroprotective properties through multiple biochemical pathways that support cognitive health and brain function. Research reveals that sesamin crosses the blood-brain barrier and accumulates in brain tissue, where it helps protect neurons from oxidative damage and supports healthy inflammatory responses [3][4]. The lignan compounds in sesame extract also modulate microglial activation, which plays a crucial role in maintaining healthy brain function and supporting Cognition throughout aging [8]. Additionally, studies indicate that sesamin supplementation may help support healthy blood lipid profiles and cardiovascular function, which are essential for optimal brain perfusion and cognitive performance [2][9].

The metabolic benefits of sesame extract extend beyond simple fat oxidation to encompass comprehensive cellular energy optimization. Animal studies demonstrate that sesamin significantly enhances hepatic fatty acid oxidation while simultaneously supporting healthy vitamin E levels in tissues [1][6]. This dual action creates a synergistic effect where improved fat metabolism is coupled with enhanced antioxidant protection, supporting overall Cellular Health Supplements and metabolic efficiency. The lignan compounds also appear to support healthy endothelial function and may help maintain healthy blood vessel integrity, contributing to overall cardiovascular wellness and optimal nutrient delivery throughout the body [9].

[1] Ashakumary L et al. Metabolism. 1999;48(10):1303-13.

[2] Shi S et al. Front Nutr. 2022;9:792714.

[3] Arabi A et al. Metab Brain Dis. 2023;38(5):1503-1511.

[4] Farbood Y et al. Life Sci. 2019;230:169-177.

[6] Kang MH et al. J Nutr. 1998;128(6):1018-22.

[8] Kongtawelert P et al. Sci Rep. 2022;12(1):11296.

[9] Ahmad S et al. Cell Biochem Funct. 2010;28(4):292-8.

Ingredients

Sesame Extract (Sesamum indicum):

• Standardized to 70% Sesamins by HPLC
• 200mg per capsule
• Concentrated lignan extract from sesame seeds

This 70% sesamin standardization represents one of the most concentrated commercially available extracts, delivering 140mg of active sesamins per capsule. Unlike whole sesame seeds or sesame oil that contain only trace amounts of these bioactive lignans, our extract concentrates these compounds to therapeutic levels. This standardization ensures consistent bioavailability of sesamin, sesamolin, and related lignans that drive the extract's metabolic and cellular health benefits.