About (-)- Epicatechin 90% + Piperine Tablets

(-)-Epicatechin 90% with Piperine combines a bioactive flavanol extract with a bioavailability enhancer for enhanced absorption. Standardized to 90% (-)-Epicatechin and paired with 6mg of Piperine per tablet, this formulation supports healthy muscle function, cardiovascular health, and cognitive performance through myostatin activity and circulation support.

Our (-)-Epicatechin Story

(-)-Epicatechin supplementation has always faced a bioavailability challenge. Research showed promising effects on muscle support through follistatin activity and myostatin pathways, but most (-)-Epicatechin gets rapidly metabolized and eliminated before reaching meaningful tissue concentrations. Even a high-quality 90% extract faces the same absorption barriers that limit this compound's potential.

Our formulation combines pharmaceutical-grade (-)-Epicatechin extract with strategically dosed Piperine to overcome these metabolic hurdles. Piperine supports p-glycoprotein function that would otherwise shuttle absorbed (-)-Epicatechin back into the intestines, while also supporting glucuronidation processes that affect the active compound. This bioavailability enhancement delivers more active (-)-Epicatechin to target tissues where it can effectively support supplements for muscle growth and cardiovascular function.

This formulation supports the muscle-building and cognitive benefits that made (-)-Epicatechin popular among fitness enthusiasts and biohackers. Instead of requiring higher doses to compensate for poor absorption, our Piperine-enhanced tablets deliver consistent, reliable effects from a practical 200mg serving.

Benefits

• Promotes Muscle Function And Strength: Supports healthy follistatin levels while supporting myostatin signaling, creating an optimal environment for muscle development and enhanced strength.
• Supports Cardiovascular Function: Promotes healthy blood flow and circulation, supporting overall heart health and vascular function through flavanol activity.
• Benefits Cognitive Performance: Supports memory and executive function through improved cerebral circulation and neuronal support mechanisms.
• Supports Physical Performance: Supports healthy energy levels and exercise capacity, with users reporting increased strength and endurance.

Piperine amplifies these benefits by supporting the sustained presence of (-)-Epicatechin in your system. Piperine supports p-glycoprotein function and glucuronidation processes, promoting bioavailability and sustained levels throughout the day.

Quality and Standardization

• 90% (-)-Epicatechin Standardization: Our tablets are standardized to 90% (-)-Epicatechin by HPLC, ensuring consistent levels of the bioactive flavanol compound in every dose.
• Piperine Enhancement Formula: Each tablet includes 6mg of Piperine to support p-glycoprotein function and glucuronidation processes, significantly improving (-)-Epicatechin bioavailability and absorption.
• Third-Party Purity Testing: We verify both product purity and identity through comprehensive laboratory testing to ensure our (-)-Epicatechin meets pharmaceutical-grade quality standards.
• Precise Tablet Formulation: Our 206mg tablets deliver exactly 200mg of (-)-Epicatechin with 6mg Piperine, providing optimal dosing consistency for reliable Fitness and cognitive support.

Mechanism of Action

• Myostatin Pathway Support: (-)-Epicatechin supports myostatin signaling through its interaction with cellular pathways that influence muscle protein synthesis, while simultaneously supporting follistatin production to create an environment conducive to muscle development.
• P-glycoprotein Activity: Piperine supports the efflux pump activity of p-glycoprotein in intestinal cells, promoting absorbed (-)-Epicatechin retention and ensuring greater systemic availability.
• Nitric Oxide Pathway Enhancement: (-)-Epicatechin promotes endothelial nitric oxide synthase (eNOS) activity, supporting nitric oxide production that promotes vasodilation and improved blood flow to both muscle and brain tissue.
• Glucuronidation Support: Piperine supports phase II detoxification enzymes that conjugate (-)-Epicatechin with glucuronic acid, supporting the compound's metabolism and extending its active presence in circulation.

Overview of the Science

(-)-Epicatechin demonstrates notable neuroprotective properties through multiple mechanisms beyond its muscle-building effects. Research suggests that this flavanol crosses the blood-brain barrier and accumulates in brain regions associated with learning and memory, where it supports cognition through enhanced cerebral blood flow and neuroplasticity. Studies indicate that (-)-Epicatechin supports a healthy neuroinflammatory response, promotes mitochondrial function, and supports cognitive function in healthy individuals [1]. The compound appears to modulate inflammatory pathways while supporting cellular energy production in neural tissue, creating an environment conducive to optimal brain function.

The inclusion of Piperine significantly enhances (-)-Epicatechin's therapeutic potential by addressing key bioavailability challenges. Without Piperine, much of the absorbed (-)-Epicatechin undergoes rapid glucuronidation and efflux back into the intestines via p-glycoprotein transporters. Piperine effectively inhibits both of these elimination pathways, allowing for sustained plasma levels of the active compound. This enhanced bioavailability translates to more pronounced effects on muscle protein synthesis, vascular function, and cognitive performance, making the combination particularly valuable for individuals seeking comprehensive support for both physical and mental performance through longevity-focused supplementation.

[1] Pang L et al. Oxid Med Cell Longev. 2022;2022:5181742.

Ingredients

Camellia sinensis Extract (leaf):

• 200mg per serving
• Standardized to 90% (-)-Epicatechin
• Enhanced with 6mg Piper nigrum Extract (95% Piperine)

The 90% (-)-epicatechin standardization represents one of the highest concentrations available, ensuring you receive 180mg of pure (-)-epicatechin per tablet. This precise standardization matters because epicatechin content can vary dramatically between different tea extracts. The addition of 95% piperine from black pepper extract supports enhanced absorption, helping your body utilize more of the epicatechin you're taking.