How Much Apigenin for Sleep? Dosage Guide & Daily Recommendations

• Evidence-Based Dosage: Human clinical research on chamomile extract (which contains apigenin) supports dosages of 400–560mg daily, typically divided into two doses of 200mg or taken as a single evening dose. Most isolated apigenin supplement recommendations (50–200mg daily) are based on theoretical calculations and animal studies, not direct human clinical trials.
• Natural Sources: Apigenin is present in chamomile tea, parsley, celery, and citrus fruits. Chamomile tea contains the highest levels, followed by parsley and celery.
• Potential Role in Relaxation: Apigenin may help support relaxation and healthy sleep patterns by interacting with certain neurotransmitter pathways.
• Safety: Apigenin is generally well-tolerated at typical supplemental levels, but possible interactions with medications should be considered.
• Quality Considerations: Choose supplements tested for purity and potency from reputable sources.

Apigenin is a naturally occurring flavonoid found in plants such as chamomile tea, parsley, celery, and citrus fruits. It is being studied for its potential to help support relaxation and maintain healthy sleep patterns. Food sources vary in apigenin content: parsley can contain up to 215.5mg per 100g, dried chamomile flowers approximately 840mg per 100g, chamomile tea 1.5–5mg per cup, celery around 2.85mg per 100g, and citrus fruits 2–5mg per 100g. Because natural content varies, standardized supplements may provide more consistent dosing for those interested in supporting relaxation and restful sleep.

Research suggests apigenin’s ability to help promote relaxation and support healthy sleep patterns may be linked to its interaction with neurotransmitter systems in the brain. Most evidence comes from studies using chamomile extract, which contains apigenin as one of its active components. Some studies suggest improvements in sleep efficiency and reductions in the time it takes to fall asleep, though these findings are primarily associated with chamomile extract rather than isolated apigenin. The exact mechanisms are still under investigation, and more human trials are needed to clarify apigenin’s specific effects on sleep in humans.

• Chamomile Extract: Human clinical trials have used chamomile extract dosages of 400–560mg daily (administered as 200mg twice daily or as a single evening dose), typically containing about 1% apigenin. This dosage may help support restful sleep.
• Isolated Apigenin: Common supplement dosages of isolated apigenin (50–200mg daily) are based on theoretical calculations and animal research, not direct human clinical trials.
• Individual Response: The optimal dosage may vary depending on body weight, metabolism, and individual sleep patterns. Starting with a lower dose and adjusting as needed is a common approach for supplements that may help support sleep.

• Timing: While specific timing research is limited, evening use may be most suitable based on the compound’s mechanisms.
• Consistency: Regular use, combined with good sleep hygiene (consistent sleep schedule, limiting stimulants, creating an optimal sleep environment), may help maintain healthy sleep patterns.
• Combination: Apigenin is sometimes combined with other supplements such as magnesium threonate or L-theanine. Always consult a healthcare professional before combining products.

• General Safety: Apigenin is generally well-tolerated at typical supplement levels. Occasional mild side effects such as drowsiness may occur.
• Medication Interactions: Apigenin may interact with certain medications, including sedatives, blood thinners, and hormonal therapies. It may affect drug metabolism in the liver and is not recommended at high doses without supervision.
• Consultation: Individuals taking medications, those with pre-existing health conditions, or those who are pregnant or breastfeeding should consult a healthcare provider before starting apigenin supplements.

Look for products that offer standardized extracts, third-party testing, and verified purity. Select supplements from reputable manufacturers that provide transparent product information and quality assurance. For those seeking a supplement, consider Nootropics Depot’s options like apigenin capsules or apigenin powder.

Preliminary research suggests apigenin may help support cognitive function, may help with stress management, and may help maintain cellular health. It may also play a role in muscle health, support brain function, and contribute to overall well-being. More research is needed to clarify these potential benefits.

Apigenin is a promising natural molecule for those seeking to support relaxation and healthy sleep patterns. Its calming effects and potential influence on mood and cellular health make it a supplement of interest for overall well-being. Consistent use of high-quality apigenin supplements, combined with good sleep hygiene, may help support restful sleep.

Because natural content varies, standardized supplements may provide more consistent dosing for those interested in supporting relaxation and restful sleep.

• Evidence-Based Dosage: Human clinical research on chamomile extract (which contains apigenin) supports dosages of 400–560mg daily, typically divided into two doses of 200mg or taken as a single evening dose. Most isolated apigenin supplement recommendations (50–200mg daily) are based on theoretical calculations and animal studies, not direct human clinical trials.
• Natural Sources: Apigenin is present in chamomile tea, parsley, celery, and citrus fruits. Chamomile tea contains the highest levels, followed by parsley and celery.
• Potential Role in Relaxation: Apigenin may help support relaxation and healthy sleep patterns by interacting with certain neurotransmitter pathways.
• Safety: Apigenin is generally well-tolerated at typical supplemental levels, but possible interactions with medications should be considered.
• Quality Considerations: Choose supplements tested for purity and potency from reputable sources.

Apigenin is a naturally occurring flavonoid found in plants such as chamomile tea, parsley, celery, and citrus fruits. It is being studied for its potential to help support relaxation and maintain healthy sleep patterns. Food sources vary in apigenin content: parsley can contain up to 215.5mg per 100g, dried chamomile flowers approximately 840mg per 100g, chamomile tea 1.5–5mg per cup, celery around 2.85mg per 100g, and citrus fruits 2–5mg per 100g. Because natural content varies, standardized supplements may provide more consistent dosing for those interested in supporting relaxation and restful sleep.

Research suggests apigenin’s ability to help promote relaxation and support healthy sleep patterns may be linked to its interaction with neurotransmitter systems in the brain. Most evidence comes from studies using chamomile extract, which contains apigenin as one of its active components. Some studies suggest improvements in sleep efficiency and reductions in the time it takes to fall asleep, though these findings are primarily associated with chamomile extract rather than isolated apigenin. The exact mechanisms are still under investigation, and more human trials are needed to clarify apigenin’s specific effects on sleep in humans.

• Chamomile Extract: Human clinical trials have used chamomile extract dosages of 400–560mg daily (administered as 200mg twice daily or as a single evening dose), typically containing about 1% apigenin. This dosage may help support restful sleep.
• Isolated Apigenin: Common supplement dosages of isolated apigenin (50–200mg daily) are based on theoretical calculations and animal research, not direct human clinical trials.
• Individual Response: The optimal dosage may vary depending on body weight, metabolism, and individual sleep patterns. Starting with a lower dose and adjusting as needed is a common approach for supplements that may help support sleep.

• Timing: While specific timing research is limited, evening use may be most suitable based on the compound’s mechanisms.
• Consistency: Regular use, combined with good sleep hygiene (consistent sleep schedule, limiting stimulants, creating an optimal sleep environment), may help maintain healthy sleep patterns.
• Combination: Apigenin is sometimes combined with other supplements such as magnesium threonate or L-theanine. Always consult a healthcare professional before combining products.

• General Safety: Apigenin is generally well-tolerated at typical supplement levels. Occasional mild side effects such as drowsiness may occur.
• Medication Interactions: Apigenin may interact with certain medications, including sedatives, blood thinners, and hormonal therapies. It may affect drug metabolism in the liver and is not recommended at high doses without supervision.
• Consultation: Individuals taking medications, those with pre-existing health conditions, or those who are pregnant or breastfeeding should consult a healthcare provider before starting apigenin supplements.

Look for products that offer standardized extracts, third-party testing, and verified purity. Select supplements from reputable manufacturers that provide transparent product information and quality assurance. For those seeking a supplement, consider Nootropics Depot’s options like apigenin capsules or apigenin powder.

Preliminary research suggests apigenin may help support cognitive function, may help with stress management, and may help maintain cellular health. It may also play a role in muscle health, support brain function, and contribute to overall well-being. More research is needed to clarify these potential benefits.

Apigenin is a promising natural molecule for those seeking to support relaxation and healthy sleep patterns. Its calming effects and potential influence on mood and cellular health make it a supplement of interest for overall well-being. Consistent use of high-quality apigenin supplements, combined with good sleep hygiene, may help support restful sleep.