About Relievex Capsules
Relievex is a comprehensive relaxation and Pain and Inflammation support supplement that combines eight targeted ingredients to support comfort and muscle relaxation. The blend features kava extract, lemon balm extract, and micronized palmitoylethanolamide alongside our exclusive tetrahydromagnolol. Unlike traditional supplements, Relievex targets the GABAergic and cannabinergic systems to promote deep muscle relaxation while maintaining mental clarity during daytime use.
Our Relievex Story
Over the years, we discovered a significant gap in natural comfort support solutions. While discomfort responds well to botanicals like Andrographis paniculata and Longvida, muscle tension and physical discomfort proved much more challenging to address effectively. We had been creating personal stacks for ourselves, friends, and family with remarkable success, which gave us the anecdotal data needed to develop a comprehensive solution.
Our breakthrough came from focusing on muscle relaxation pathways rather than just supporting a healthy inflammatory response. Relievex targets both GABAergic and cannabinergic systems, which play crucial roles in comfort and physical tension. By combining proven ingredients like ginger extract and maca extract with our proprietary tetrahydromagnolol, we created a formula that produces deep muscle relaxation while supporting Mood and maintaining functional energy levels throughout the day.
Benefits
- Supports Comfort: Relievex supports physical comfort through the GABAergic and cannabinergic systems, with micronized palmitoylethanolamide providing particularly strong support for overall physical comfort.
- Supports a Healthy Inflammatory Response: Ginger extract and supercritical CO2 boswellia extract work together to support healthy inflammatory responses while creating a warm, soothing sensation throughout the body.
- Supports Sleep: The blend promotes deep physical relaxation through GABA receptor activation from kava extract and GABA elevation via lemon balm extract, making it easier to fall asleep when discomfort keeps you awake.
- Supports a Positive Mood: Relievex produces a unique mood-supporting effect by combining physical relaxation with mental clarity, creating a profound sense of calm that takes the edge off during stressful periods without inducing lethargy.
The formula includes maca extract to provide gentle mental energy while maintaining deep physical relaxation, and tetrahydromagnolol, an exclusive compound that enhances CB2 receptor activity for additional comfort support. This combination allows Relievex to remain functional for daytime use while providing the flexibility to increase the dose for more pronounced evening relaxation.
Quality and Standardization
- Multi-Component Standardization: We standardize each of the eight ingredients in Relievex to precise specifications, including our kava extract at 30% kavalactones and micronized PEA for optimal bioavailability.
- Advanced Extraction Methods: Our supercritical CO2 boswellia extraction specifically targets TRPV3 receptor activation while our proprietary tetrahydromagnolol represents a unique hydrogenated form of magnolol we've developed exclusively.
- Comprehensive Laboratory Testing: Every batch undergoes rigorous testing for purity, potency, and identity verification through our third-party labs to ensure consistent effects across all eight synergistic compounds.
- Bioavailability Enhancement: We include piperine extract based on extensive user feedback comparing formulations with and without this absorption enhancer, consistently demonstrating superior effectiveness in the final blend.
Mechanism of Action
- GABAergic System Enhancement: Kava activates GABA receptors directly while lemon balm extract inhibits GABA transaminase, the enzyme that breaks down GABA into glutamate, creating a dual pathway for enhanced GABAergic activity and deep muscle relaxation.
- Cannabinoid System Modulation: Micronized palmitoylethanolamide acts as an endocannabinoid while maca extract inhibits fatty acid amide hydrolase (FAAH), preventing endocannabinoid breakdown and supporting the body's natural comfort pathways.
- CB2 Receptor Targeting: Tetrahydromagnolol, created through hydrogenation of magnolol, demonstrates significantly stronger CB2 receptor agonism than its parent compound, specifically targeting comfort support without psychoactive effects.
- Vanilloid Receptor Interaction: Ginger extract modulates vanilloid receptors to support comfort while our supercritical CO2 boswellia extract activates TRPV3 receptors, creating a warming sensation that promotes muscle relaxation through thermoreceptor pathways.
- Bioavailability Enhancement: Piperine works through multiple mechanisms including inhibition of drug-metabolizing enzymes and increased intestinal absorption, ensuring optimal uptake of all eight active compounds in this stress and comfort support formula.
Overview of the Science
Research demonstrates that Relievex's targeted ingredients work through multiple pathways to support the body's natural comfort systems. Studies indicate that palmitoylethanolamide (PEA) supports physical comfort, with meta-analyses revealing consistent benefits for both ongoing and acute physical discomfort [1][2]. The endocannabinoid compound works particularly well for nerve-related comfort by supporting healthy comfort perception at the cellular level. Meanwhile, our standardized kava extract provides kavalactones that interact with both GABA and cannabinoid CB1 receptors, creating a dual pathway for physical and mental relaxation.
The inclusion of tetrahydromagnolol represents advanced research into cannabinoid receptor modulation. Studies indicate that magnolia-derived compounds activate cannabinoid CB2 receptors while supporting a healthy inflammatory response [3]. Our proprietary hydrogenation process creates tetrahydromagnolol, which shows enhanced CB2 receptor binding compared to standard magnolol. This selective CB2 activation supports comfort modulation without the psychoactive effects associated with CB1 receptor activity. Additionally, clinical research on andrographis compounds supports their role in promoting a healthy inflammatory response, with controlled trials showing significant benefits for joint comfort and mobility [4][5].
The synergistic combination creates effects that individual ingredients cannot achieve alone. Lemon balm's GABA-T inhibition elevates natural GABA levels while maca's FAAH inhibitory macamides preserve endocannabinoids, creating sustained activity throughout the day. Research on magnolia compounds confirms their comfort-supporting properties in both acute and inflammatory models [6]. This multi-target approach addresses the complexity of comfort perception by supporting natural neurotransmitter balance, endocannabinoid function, and healthy inflammatory response pathways simultaneously. The addition of piperine enhances bioavailability across all active compounds, ensuring optimal absorption for maximum benefit.
[1] Lang-Illievich K, Klivinyi C, Lasser C, Brenna CTA, Szilagyi IS, Bornemann-Cimenti H. Palmitoylethanolamide in the Treatment of Chronic [...]: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials. Nutrients. 2023;15(6):1350.
[2] Artukoglu BB, Beyer C, Zuloff-Shani A, Brener E, Bloch MH. Efficacy of Palmitoylethanolamide for [...]: A Meta-Analysis. [...] Physician. 2017;20(5):353-362.
[3] Rempel V, Fuchs A, Hinz S, Karcz T, Lehr M, Koetter U, Müller CE. Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55. ACS Med Chem Lett. 2013;4(1):41-5.
[4] Burgos RA, Hancke JL, Bertoglio JC, Aguirre V, Arriagada S, Calvo M, Cáceres DD. Efficacy of an Andrographis paniculata composition for the relief of [...] symptoms: a prospective randomized placebo-controlled trial. Clin Rheumatol. 2009;28(8):931-46.
[5] Gupte PA, Giramkar SA, Harke SM, Kulkarni SK, Deshmukh AP, Hingorani LL, Mahajan MP, Bhalerao SS. Evaluation of the efficacy and safety of Capsule Longvida® Optimized Curcumin (solid lipid curcumin particles) in knee [...]: a pilot clinical study. J Inflamm Res. 2019;12:145-152.
[6] Lin YR, Chen H, Ko CH. Effects of honokiol and magnolol on acute and inflammatory [...] models in mice. Life Sci. 2007;81(15):1071-8.
Ingredients
- Premium water-based kava extract that maintains the traditional preparation method while concentrating active compounds
- Ingredient source: Piper methysticum root
- Amount per serving: 500mg
- Standardization: 10% Kavalactones
- Primary benefit: Supports relaxation and stress relief through traditional Pacific island botanical wisdom
- Concentrated whole plant extract from the calming mint family herb
- Ingredient source: Melissa officinalis whole plant
- Amount per serving: 250mg
- Standardization: 1% Rosmarinic Acid
- Primary benefit: Promotes calm focus and supports healthy sleep quality
- Supercritical CO2 extraction preserves the full spectrum of ginger's bioactive compounds
- Ingredient source: Zingiber officinale rhizome
- Amount per serving: 200mg
- Standardization: 10% Gingerols & Shogaols
- Primary benefit: Supports digestive comfort and healthy inflammatory response
- Ultra-fine particle size enhances bioavailability of this naturally occurring fatty acid amide
- Ingredient source: Synthetic palmitoylethanolamide
- Amount per serving: 200mg
- Primary benefit: Supports the body's natural endocannabinoid system and comfort levels
- Concentrated extract from the Peruvian adaptogenic root
- Ingredient source: Lepidium meyenii root
- Amount per serving: 100mg
- Standardization: 5% Macamides
- Primary benefit: Supports energy balance and overall vitality
- Advanced CO2 extraction captures the full resin profile of frankincense
- Ingredient source: Boswellia sacra resin
- Amount per serving: 100mg
- Standardization: 20% Boswellic Acids, 5% AKBA, 8% Cembrenes
- Primary benefit: Supports healthy inflammatory response and joint comfort
- Standardized magnolia bark compound known for its calming properties
- Ingredient source: Magnolia officinalis bark
- Amount per serving: 10mg
- Primary benefit: Promotes relaxation and supports healthy stress response
- Black pepper extract that enhances absorption of other botanical compounds
- Ingredient source: Piper nigrum seed
- Amount per serving: 6mg
- Primary benefit: Improves bioavailability and absorption of the complete formula
Pain Support
Inflammation
Sleep
Mood
