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Perluxan softgels contain a proprietary hops resin extract standardized to alpha acids which are key components for supporting pain relief.
The alpha acids in Perluxan have notable fast-acting effects on joint discomfort and mild aches and pains, making Perluxan for pain relief a great option for pain management.
Perluxan softgels are a unique, all-natural supplement primarily used to support joint health and soothe daily aches and pains. They contain a proprietary hops resin extract standardized to alpha acids, clinically demonstrated to have a fast-acting pain-relieving effect, without causing GI distress. Many consumers reach for remedies that inhibit the cyclooxygenase or COX enzymes, which are responsible for discomfort. Unfortunately, these remedies are not typically selective; they inhibit both the COX-1 and COX-2 enzymes with varying intensity. So, while discomfort may be reduced by blocking the COX-2 enzyme, nonselective inhibition of COX-1, whose job is to protect the gastro-intestinal (GI) tract lining, can lead to GI-related adverse events. There are selective COX-2 inhibitors — substances that shut down COX-2 enzymes but not COX-1. Unfortunately, these have even more dangerous side effects. The problem is that they are too selective. By completely shutting down COX-2, these remedies are theorized to suppress production of cardio-protective enzymes, thus endangering the heart.
The next step in evaluating Perluxan’s efficacy was to conduct a Williams Harvey Modified Whole Blood Assay — considered the “gold standard” for evaluating a substance’s COX activity and selectivity. There were three possible outcomes: 1. If Perluxan moderately inhibited both COX-1 and COX-2, then it could be assumed to cause GI problems. 2. If Perluxan shut down COX-2 completely without affecting COX-1, it could be assumed to increase the risk of cardiovascular events. 3. However, if Perluxan could moderately inhibit COX-2 while only mildly inhibiting COX-1, then the researchers would have a winner. The results? Perluxan achieved the perfect middle ground. It inhibited COX-2 strongly enough to be able to alleviate discomfort, but not so strongly that it shut down the enzyme altogether.* And it only mildly inhibited COX-1, so GI toxicity was extremely unlikely. This would make Perluxan for pain relief an ideal option for those looking to promote joint health with minimal chance of GI toxicity.
Having passed these initial hurdles, Perluxan was ready for the final test: human clinical trials. Human trials taking Perluxan for pain demonstrated quick relief and significant improvement over placebo could be measured after only two hours after the first dose. Perluxan is a proprietary supercritical hops extract standardized to contain a specific amount of alpha acids — the active constituents — and designed to be virtually free of phytoestrogenic and sleep-inducing compounds. In vitro testing, utilizing the CACO-2 cell monolayer assay, indicates that the permeability of the alpha acids contained in Perluxan is high. High permeability predicts good human oral bioavailability. Perluxan’s safety has been confirmed in a double-blind placebo-controlled human clinical trial. The comparison of pre and post-supplementation blood work, as well as adverse side effect monitoring, showed that Perluxan was well-tolerated and led to no GI discomfort. Additionally, studies in rats and dogs have demonstrated that hops alpha acids caused no changes in hematological examinations, blood chemistry, urine tests, or pathological examinations, and are non-toxic even in doses that far exceed the amount found in Perluxan. Hops alpha acids have also tested negative for mutagenicity (the ability to cause mutations) and genotoxicity (the ability to cause genetic damage).
|Serving Size: 2 Softgel Capsules||Amount Per Serving||% Daily Value|
|Hops Extract (80% Alpha Acids)||300mg||*|
*No Daily Value Established
**Based on 2,000 Calorie Diet
As a dietary supplement, take two 300mg Perluxan Hops Resin Extract capsules daily.
Product contains one (1) 60ct. or 120ct. jar of Perluxan™ (Proprietary Hops Resin Extract) Softgel Capsules
To gain more insight, see the Perluxan Hops Resin Extract reviews and experiences below.
Nootropics Depot offers 60ct. or 120ct. jars of Perluxan Hops Resin Extract Softgel Capsules. Nootropics Depot's Hops Resin Extract has been lab-tested and verified for both product purity and identity.
ATTENTION: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
My left elbow started to bother me a bit. I had been taking a joint formula which has been working well overall but for some reason the left elbow pain just was not going away. I started Perluxin and did notice some relief.at 1 dose per day. At some point I decided to try 2 divided doses each day. The Doses were 2 soft gels to start and then 4 hours later 2 more soft gels, . The second dose kicks in very nicely and that little annoying pain in the left elbow goes t away. If I do not do the divided doses each day, then the pain does come back, This stuff does work you just have to stay on it and maybe try the 2 divided doses each day. No noticeable negative effect with the 2 divided doses per day. Unknown on 6th Jun 2018
It doesn't produce much effect though I use it only for sleep..
Can't say it does ant better or worse..
ND Admin: Perluxan is standardized to alpha acids. For sleep, beta acids are better. We will bring out a high beta acid hops extract at some point. Barak Skop on 9th Dec 2017
hops extract has been demonstrated to help with sleep/wake and I've found it helpful for this purpose, very much so.
srubek on 9th Oct 2016
It does what it says when you take it everyday for a couple of weeks.
Not sure if it is supposed to be taken with food or without. Trying both, both for bioavailability mysteries, and it may or may not cause an upset stomach occasionally. Unknown on 2nd Oct 2016