About Pregnenolone Tablets

Pregnenolone is the master steroid hormone precursor, serving as the first step in virtually all hormone synthesis pathways from cholesterol. Our quick dissolve micronized tablets deliver 5mg of pregnenolone that bypasses the rate-limiting cholesterol conversion step, supporting healthy levels of DHEA, testosterone and other downstream hormones while acting as a potent neurosteroid that modulates cognitive function and mood through sigma-1 receptor activation.

Our Pregnenolone Story

Most pregnenolone supplements on the market use massive doses of 100mg or higher, assuming more is always better. Our research revealed that escalating pregnenolone doses actually shut off androgen production pathways while driving only progesterone synthesis. High-dose pregnenolone becomes anti-androgenic rather than pro-androgenic, defeating the primary purpose most users seek.

We formulated pregnenolone at precisely 5mg to target the sweet spot where you enhance all steroid hormone pathways without triggering negative feedback mechanisms that occur at higher doses. This dose allows pregnenolone to fulfill its role as a master hormone precursor while delivering its potent neurosteroid effects through sigma-1 receptor agonism and NMDA positive allosteric modulation. The result supports both hormonal balance and cognitive enhancement without the counterproductive effects seen with mega-dose formulations.

Benefits

• Supports Healthy Inflammatory Response: Pregnenolone converts to allopregnanolone, a potent GABAA receptor modulator that supports the body's natural inflammatory response pathways and promotes cellular balance.
• Supports Cognition: Acts as a sigma-1 receptor agonist while converting to pregnenolone sulfate, which functions as an NMDA positive allosteric modulator to enhance long-term potentiation and cognitive processing.
• Supports Mood: Sigma-1 receptor activation combined with allopregnanolone's GABAA modulation creates mood-supporting effects that promote emotional balance and well-being.
• Supports Memory: Pregnenolone sulfate's NMDA receptor enhancement facilitates long-term potentiation (LTP), the cellular mechanism underlying memory formation and encoding.

The quick dissolve micronized formulation enhances bioavailability, allowing pregnenolone to efficiently cross the blood-brain barrier and exert its neurotransmitter modulating effects. This neurosteroid activity complements its role in hormone synthesis, making it valuable for both cognitive enhancement and vitality supplements protocols.

Quality and Standardization

• Micronized Quick Dissolve Formula: Our pregnenolone tablets feature micronized particles for rapid dissolution and enhanced bioavailability, ensuring optimal absorption when taken sublingually or swallowed.
• 5mg Precision Dosing: Each tablet delivers exactly 5mg of pregnenolone, carefully formulated to support pro-androgenic effects while avoiding the anti-androgenic outcomes associated with higher doses that preferentially drive progesterone synthesis.
• Third-Party Testing: Every batch undergoes rigorous purity and identity verification through third-party labs to ensure consistent potency and freedom from contaminants.
• Rate-Limiting Step Bypass: By providing pregnenolone directly, we circumvent the cholesterol-to-pregnenolone conversion bottleneck, allowing for enhanced downstream vitality supplements synthesis pathways.

Mechanism of Action

• Cholesterol Side-Chain Cleavage Enhancement: Pregnenolone bypasses the rate-limiting step in steroid hormone synthesis by providing the direct precursor molecule, eliminating the need for cholesterol-to-pregnenolone conversion via CYP11A1 enzyme activity.
• Sigma-1 Receptor Agonism: Acts as a direct agonist at sigma-1 receptors in the brain, modulating cellular stress responses, protein folding, and calcium signaling pathways that influence memory formation and cognitive flexibility.
• NMDA Positive Allosteric Modulation: Converts to pregnenolone sulfate, which enhances NMDA receptor function through positive allosteric modulation, facilitating long-term potentiation processes essential for learning and memory encoding.
• GABAA Receptor Modulation: Metabolizes to allopregnanolone, a potent positive allosteric modulator of GABAA receptors that supports balanced neural excitability and promotes neurotransmitter homeostasis.

Overview of the Science

Research demonstrates pregnenolone's significant impact on cognitive function through multiple neurosteroid pathways [1][2]. Studies show pregnenolone sulfate acts as a positive allosteric modulator of NMDA receptors, enhancing long-term potentiation and memory formation [1]. Additionally, pregnenolone's agonist activity at sigma-1 receptors contributes to improved mood regulation and cognitive performance [2][3]. Animal studies indicate pregnenolone supplementation enhances memory consolidation and learning capacity, with effects observed across multiple memory tasks [4].

Clinical research has explored pregnenolone's therapeutic potential in various cognitive conditions. A proof-of-concept trial demonstrated pregnenolone's ability to support cognitive function and improve negative symptoms in neuropsychiatric conditions [5]. Recent research has also highlighted pregnenolone's role in hypothalamic function, where it mediates recognition memory processes and supports metabolic health [6]. These findings suggest pregnenolone may benefit both cognitive performance and overall metabolic function through central nervous system mechanisms.

The neurosteroid allopregnanolone, derived from pregnenolone metabolism, acts as a potent positive allosteric modulator of GABAA receptors, supporting healthy neurotransmission and stress response regulation [7]. This GABAA modulation contributes to pregnenolone's calming effects while maintaining cognitive clarity. Research confirms that neurosteroids like pregnenolone and its metabolites serve as endogenous effectors for multiple receptor systems, creating a comprehensive approach to cognitive and mood support [8].

[1] Wu FS, Gibbs TT, Farb DH. Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor. Mol Pharmacol. 1991;40(3):333-336.

[2] Maurice T, Urani A, Phan VL, Romieu P. The interaction between neuroactive steroids and the sigma1 receptor function: behavioral consequences and therapeutic opportunities. Brain Res Rev. 2001;37(1-3):116-132.

[3] Dhir A, Kulkarni SK. Involvement of sigma (σ1) receptors in modulating the anti-depressant effect of neurosteroids (dehydroepiandrosterone or pregnenolone) in mouse tail-suspension test. J Psychopharmacol. 2008;22(6):691-696.

[4] Flood JF, Morley JE, Roberts E. Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proc Natl Acad Sci USA. 1992;89(4):1567-1571.

[5] Marx CE, Keefe RSE, Buchanan RW, Hamer RM, Kilts JD, Bradford DW, Strauss JL, Naylor JC, Payne VM, Lieberman JA, Savitz SI, Leimone LA, Dunn L, Porcu P, Morrow AL, Shampine LJ. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology. 2009;34(8):1885-1903.

[6] Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Konstantinova P, Watanabe M, Belsham DD, Loureiro M, Milagro FI, Burks DJ, Diéguez C, Claret M. Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders. Cell Metab. 2022;35(2):263-280.

[7] Belelli D, Herd MB, Mitchell EA, Peden DR, Vardy AW, Gentet L, Lambert JJ. Neuroactive steroids and inhibitory neurotransmission: mechanisms of action and physiological relevance. Neuroscience. 2006;138(3):821-829.

[8] Maurice T, Grégoire C, Espallergues J. Neuroactive neurosteroids as endogenous effectors for the sigma1 (σ1) receptor: pharmacological evidence and therapeutic opportunities. Jpn J Pharmacol. 1999;81(2):125-155.

Ingredients

Pregnenolone:

• Pregnenolone (steroid hormone precursor)
• 5mg per tablet
• Micronized for enhanced dissolution

Our micronized pregnenolone tablets utilize particle size reduction technology to create faster-dissolving formulations with superior bioavailability compared to standard pregnenolone powders. The 5mg dosing provides an optimal amount for supporting the body's natural hormone support pathways without overwhelming endogenous production systems. This precise micronization process ensures consistent dissolution whether taken sublingually for rapid absorption or swallowed conventionally, making it suitable for various supplementation preferences and vitality supplements protocols.