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Pain Supplements Buying Guide

Recommended Pain Supplements By Type

Recommended Pain Supplements By Type

Choose Your Type Of Pain Below To View Our Top Recommended Pain Supplements

Choose Your Type Of Pain Below To View Our Top Recommended Pain Supplements

🎯Acute Pain

Every once in a while, we find ourselves in a situation where we are experiencing higher than normal levels of pain out of nowhere. For example, when we pull a muscle in our back. In this situation, we need all the help we can get, and preferably as quickly as possible! The following three supplements are our most powerful pain management supplements, and get to work in less than an hour!

Quick & Robust*

Relax Muscles*

Learn More

Supercritical Myrrh

This extract is a unique supercritical CO2 extraction of myrrh, offering robust and fast-acting pain relief while effectively reducing inflammation.*
Read More >>

Kava

Our Kava is a potent
water extract formulation, promoting muscle relaxation through GABAergic and cannabinergic pathways, while delivering a powerful and rapid dampening effect on inflammation.*
Read More>>

Matrine

Derived from Sophora flavescens, Matrine is a distinctive alkaloid known for its rapid pain relief and swift anti-inflammatory effects.*
Read more >>

💪 For Delayed Onset Muscle Soreness (DOMS)*

Working out is great, but sometimes that delayed onset muscle soreness (DOMS) can make us feel like we got hit by a truck! This can not only make it hard to walk around after a heavy leg day, but it can also make it tough to get back into the gym to get another workout in. Luckily, there are quite a few supplements that can help enhance the recovery process, thereby dampening DOMS!

Daily Balanced*

Strength & Pain*

Learn More

Tart Cherry

Tart Cherry is rich in beneficial anthocyanins and helps to balance inflammation and oxidation while also lowering uric acid levels.*
Learn More >>

Beta-Ecdysterone

Beta-Ecdysterone enhances anabolism through a unique estrogenic mechanism, effectively reducing DOMS and providing a significant boost in strength!*
Read More>>

Epicatechin

Epicatechin, a powerful myostatin inhibitor, efficiently balances oxidation levels and proves highly beneficial for body recomposition.*
Read more >>

🧬 For Endocannabinoid System Support *

One of the most important pain regulating systems in our bodies is the endocannabinoid system. We have lots of endocannabinoid compounds floating around in our bodies that are crucial for pain management, such as palmitoylethanolamide, anandamide, and 2-AG. Thus, a great strategy for pain management is to support the endocannabinoid system. Luckily, there are quite a few supplements that can have a supportive effect on the endocannabinoid system!

EPA & DHA*

Energy & Pain*

Learn More

Availom EPA

Availom offers a high bioavailability formulation of EPA, a precursor to numerous endocannabinoids, and also includes DHA, another crucial endocannabinoid precursor.*
Read More >>

Maca

Maca features a concentrated macamide extract that inhibits FAAH, leading to heightened endocannabinoid levels, and concurrently activates cannabinoid CB1 receptors.*
Read More>>

Rephyll

Rephyll boasts a high bioavailability formulation of beta-caryophyllene, proficiently inhibiting monoacylglycerol lipase to increase endocannabinoid levels, while also activating CB2 receptors.*
Read more >>

🔥 For Inflammation*

Balancing inflammation levels on a daily basis can be a great strategy for the management of long-term, low-level pain. This is especially the case for joint pain. The following supplements are our favorite inflammation-balancing supplements, which are ideal for daily use!

Respiratory & Pain*

Cognition & Pain*

Learn More

Andrographis

Andrographis is a highly potent extract of Andrographis paniculata, delivering a strong anti-inflammatory effect while also promoting optimal respiratory function.*
Read More >>

Longvida

Longvida presents a high bioavailability formulation of curcumin, making it an excellent option for sustained inflammation management, while also providing notable
benefits for cognitive function.*
Read More>>

Vignatex

Vignatex features an exclusive blend of mung bean extract, which efficiently slows the production of pro-inflammatory cytokines, while also providing a boost in focus and energy.*
Read more >>

🦵 For Joint Pain*

One of the most common types of pain, especially as we age, is joint pain. Luckily, there are quite a few supplement options which can help dampen joint pain. The trick to putting together a high performance strategy for joint pain management is to focus on long term joint health. Luckily, there are some excellent options for supplements which can both dampen joint pain and enhance joint function!

High Bioavailability*

Clinically Studied*

Learn More

Meriva

Meriva Curcumin Phytosome boasts a distinctive formulation, utilizing phytosome technology to ensure high bioavailability, and it has been clinically studied for its effectiveness in promoting joint health and alleviating pain.*
Read More >>

Casperome

Incorporating a unique phytosome formulation of Boswellia serrata, Casperome offers high bioavailability and has undergone clinical studies for its efficacy in promoting joint health and alleviating pain.*
Read More>>

Injuv

Injuv presents a high bioavailability formulation of hyaluronic acid, which effectively lubricates joints and proves excellent for providing long-term support for joint health.*
Read more >>

🦠 For Nerve Pain*

Pain comes in many different flavors, with nerve pain being one of the trickiest to manage. This is due to the fact that special attention needs to be paid to enhancing nerve health in order for a long term nerve pain management strategy to be effective. Simply masking nerve pain is thus not good enough. Luckily, we have some excellent products that can help enhance nerve health, while also helping to dampen nerve related pain!

Long-Term Use*

Increases NGF*

Learn More

PEA

PEA is an endocannabinoid that is excellent for long-term pain management, with effects typically taking 1-2 weeks to fully develop.*
Read More >>

Erinamax

Erinamax elevates NGF levels, offering acute relief from nerve-related pain, while also promoting long-term pain management through the facilitation of nerve regeneration.*
Learn More>>

OptimALA

OptimALA is a potent formulation of alpha lipoic acid that effectively alleviates nerve pain through its oxidation-regulating effects, while also supporting long-term pain management by promoting nerve regeneration.*
Read more >>

💧 For Oxidation*

Oxidative stress is oftentimes the most neglected aspect of pain management, however, it plays a crucial role in the overall pain response. By dampening oxidation levels, we can already expect a significant pain management effect, however, the real magic comes when oxidation balancing supplements are combined with inflammation balancing supplements! Here are some of our favorite oxidation lowering supplements that can make for great stand alone pain management strategies, and work even better in more comprehensive strategies when combined with an inflammation balancing supplement.

Immune & Pain*

Great For Stacking*

Learn More

Infini-C

Infini-C is a high bioavailability formulation of vitamin C, a crucial antioxidant in the body, and is also highly effective in supporting immune function.*
Read More >>

NAC

NAC rapidly elevates glutathione levels, providing
distinctive
oxidation balancing effects through H2S,
and enhances the efficacy of other pain
management supplements.*
Read More>>

OptimALA

OptimALA is a potent formulation of alpha lipoic acid that effectively alleviates nerve pain through its oxidation-regulating effects, while also supporting long-term pain management by promoting nerve regeneration.*
Read more >>

😣 Tension Pain*

With our busy lifestyles, there often comes a time when our muscles gradually start to tense up. Especially in our shoulders, and neck. This oftentimes leads to a very annoying low level of pain, which can be distracting and add to the sensation of daily stress. Luckily, there are quite a few supplements which can help ease this muscle tension!

Relax Muscles*

Quick Dissolve*

Learn More

Kava

Our Kava is a potent water extract formulation, promoting muscle relaxation through GABAergic and cannabinergic pathways, while delivering a powerful and rapid dampening effect on inflammation.*
Read More>>

Tetrahydromagnolol

Tetrahydromagnolol, a distinctive compound derived from Magnolia bark metabolism, induces muscle relaxation by activating cannabinoid CB2 receptors, with the advantage of quick-dissolve
tablets for rapid effects.*
Read More>>

Mitidol

Mitidol is a novel groundbreaking formulation combining ginger and acmella, effectively relaxing muscles through the activation of cannabinoid CB2 receptors, while also delivering a mild
inflammation-reducing effect.*
Read more >>

🎯Acute Pain

Every once in a while, we find ourselves in a situation where we are experiencing higher than normal levels of pain out of nowhere. For example, when we pull a muscle in our back. In this situation, we need all the help we can get, and preferably as quickly as possible! The following three supplements are our most powerful pain management supplements, and get to work in less than an hour!

Quick & Robust*

Relax Muscles*

Learn More

Supercritical Myrrh

This extract is a unique supercritical CO2 extraction of myrrh, offering robust and fast-acting pain relief
while effectively reducing inflammation.*
Read More >>

Kava

Our Kava is a potent
water extract formulation, promoting muscle relaxation through GABAergic and cannabinergic pathways, while delivering a powerful and rapid dampening effect on inflammation.*
Read More>>

💪 For Delayed Onset Muscle Soreness (DOMS)*

Working out is great, but sometimes that delayed onset muscle soreness (DOMS) can make us feel like we got hit by a truck! This can not only make it hard to walk around after a heavy leg day, but it can also make it tough to get back into the gym to get another workout in. Luckily, there are quite a few supplements that can help enhance the recovery process, thereby dampening DOMS!

Daily Balanced*

Strength & Pain*

Learn More

Tart Cherry

Tart Cherry is rich
in beneficial anthocyanins and helps to balance inflammation and oxidation while also lowering uric
acid levels.*
Learn More >>

Beta-Ecdysterone

Beta-Ecdysterone enhances anabolism through a unique estrogenic mechanism, effectively reducing DOMS and providing a significant boost in strength!*
Read More>>

🧬 For Endocannabinoid System Support *

One of the most important pain regulating systems in our bodies is the endocannabinoid system. We have lots of endocannabinoid compounds floating around in our bodies that are crucial for pain management, such as palmitoylethanolamide, anandamide, and 2-AG. Thus, a great strategy for pain management is to support the endocannabinoid system. Luckily, there are quite a few supplements that can have a supportive effect on the endocannabinoid system!

EPA & DHA*

Energy & Pain*

Learn More

Availom EPA

Availom offers a high bioavailability formulation of EPA, a precursor
to numerous endocannabinoids, and also includes DHA, another crucial endocannabinoid precursor.*
Read More >>

Maca

Maca features a concentrated macamide extract that inhibits FAAH, leading to heightened endocannabinoid levels, and concurrently activates cannabinoid CB1 receptors.*
Read More>>

🔥 For Inflammation*

Balancing inflammation levels on a daily basis can be a great strategy for the management of long-term, low-level pain. This is especially the case for joint pain. The following supplements are our favorite inflammation-balancing supplements, which are ideal for daily use!

Respiratory & Pain*

Cognition & Pain*

Learn More

Andrographis

Andrographis is a highly potent extract of Andrographis paniculata, delivering a strong anti-inflammatory effect while also promoting optimal respiratory function.*
Read More >>

Longvida

Longvida presents a high bioavailability formulation of curcumin, making it an excellent option for sustained inflammation management, while also providing notable benefits for cognitive function.*
Read More>>

🦵 For Joint Pain*

One of the most common types of pain, especially as we age, is joint pain. Luckily, there are quite a few supplement options which can help dampen joint pain. The trick to putting together a high performance strategy for joint pain management is to focus on long term joint health. Luckily, there are some excellent options for supplements which can both dampen joint pain and enhance joint function!

High Bioavailability*

Clinically Studied*

Learn More

Meriva

Meriva Curcumin Phytosome boasts a distinctive formulation, utilizing phytosome technology to ensure high bioavailability, and it has been clinically studied for its effectiveness in promoting joint health and alleviating pain.*
Read More >>

Casperome

Incorporating a unique phytosome formulation of Boswellia serrata, Casperome offers high bioavailability and has undergone clinical studies for its efficacy in promoting joint health and alleviating pain.*
Read More>>

🦠 For Nerve Pain*

Pain comes in many different flavors, with nerve pain being one of the trickiest to manage. This is due to the fact that special attention needs to be paid to enhancing nerve health in order for a long term nerve pain management strategy to be effective. Simply masking nerve pain is thus not good enough. Luckily, we have some excellent products that can help enhance nerve health, while also helping to dampen nerve related pain!

Endocannabinoid*

Increases NGF*

Learn More

PEA

PEA is an endocannabinoid that is excellent for long-term pain management, with effects typically taking 1-2 weeks to fully develop.*
Read More >>

Erinamax

Erinamax elevates NGF levels, offering acute relief from nerve-related pain, while also promoting long-term pain management through the facilitation of nerve regeneration.*
Learn More>>

💧 For Oxidation*

Oxidative stress is oftentimes the most neglected aspect of pain management, however, it plays a crucial role in the overall pain response. By dampening oxidation levels, we can already expect a significant pain management effect, however, the real magic comes when oxidation balancing supplements are combined with inflammation balancing supplements! Here are some of our favorite oxidation lowering supplements that can make for great stand alone pain management strategies, and work even better in more comprehensive strategies when combined with an inflammation balancing supplement.

Immune & Pain*

Great For Stacking*

Learn More

Infini-C

Infini-C is a high bioavailability formulation of vitamin C, a crucial antioxidant in the body, and is also highly effective in supporting immune function.*
Read More >>

NAC

NAC rapidly elevates glutathione levels, providing distinctive oxidation-balancing effects through H2S, and enhances the efficacy of other pain management supplements.*
Read More>>

😣 Tension Pain*

With our busy lifestyles, there often comes a time when our muscles gradually start to tense up. Especially in our shoulders, and neck. This oftentimes leads to a very annoying low level of pain, which can be distracting and add to the sensation of daily stress. Luckily, there are quite a few supplements which can help ease this muscle tension!

Relax Muscles*

Quick Dissolve*

Learn More

Kava

Our Kava is a potent
water extract formulation, promoting muscle relaxation through GABAergic and cannabinergic pathways, while delivering a powerful and rapid dampening effect on inflammation.*
Read More>>

Tetrahydromagnolol

Tetrahydromagnolol, a distinctive compound derived from Magnolia bark metabolism, induces muscle relaxation by activating cannabinoid CB2 receptors, with the advantage of quick-dissolve tablets for rapid effects.*
Read More>>


Learn More About Pain
Supplements & Managing Pain

Learn More About Pain Supplements & Managing Pain

Discover the science behind pain with Emiel and Erika on our podcast In Search Of Insight.

Discover the science behind pain with Emiel and Erika on our podcast In Search Of Insight.

THE BORING STUFF NOBODY READS BUT PROBABLY SHOULD

**SCOOPS: Nootropics Depot does not provide scoops or spoons with any of our products. Scoops are highly unreliable for accurate measuring. Mama didn't raise no fool! Scoops measure volume rather than weight, which is problematic because all powders have different densities. You wouldn't use a spoon to weigh yourself, would you? A milligram scale is needed to accurately measure powder products. Tools set us apart from the animals.

WARNING: Keep all supplements out of reach of children. Kids are short and stupid, so that should be easy for you. Do not take any supplement if under the age of 18, pregnant or nursing a baby (or an adult for that matter), or if you have any known or suspected medical conditions, and/or taking prescription drugs or over the counter medications.

*DISCLAIMER: Always consult with a qualified health physician before taking any new dietary supplement. If you can't find a qualified one, try an unqualified one. The products and statements found on this page are not intended to diagnose, treat, cure, or prevent any diseases. You hear that FDA? We are not talking about diseases! These statements have not been evaluated by the Food and Drug Administration, nor would we want them to.

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