null
Palmitoylethanolamide: A Guide To Its Pain Management Benefits And Beyond

Palmitoylethanolamide: A Guide To Its Pain Management Benefits And Beyond

Posted by Nootropics Depot on 15th May 2020

WHAT IS PALMITOYLETHANOLAMIDE?

Often abbreviated as PEA, Palmitoylethanolamide is a natural substance found in the body that may support pain management. Palmitoylethanolamide (PEA) was discovered in 1957 and it was referred to as N-(2-hydroxyethyl)-palmitamide at the time. Let's take a closer look at this intriguing natural molecule.

WHY CHOOSE PEA AS YOUR PAIN MANAGEMENT SUPPLEMENT OF CHOICE?

PEA is an endogenous fatty acid amide, and a member of the N-acetyl-ethanolamine family. Fatty acid amides are created from a combination of a fatty acid and an amine. Fatty acid amides are widely circulated in the body, and have a key role in biochemical signalling. Although PEA is an endogenous compound found throughout the human body, Palmitoylethanolamide can be found in foods too. The most common Palmitoylethanolamide food sources are milk and eggs. However, Palmitoylethanolamide is only present in these foods at trace amounts and does not promote significant PEA benefits.

Interestingly enough, hypersensitivity to pain is associated with a large decrease in PEA levels in the brain and spinal cord, areas directly and indirectly involved in helping the nervous system from potentially harmful stimuli. This seems to indicate that PEA may be vital in bodily responses to pain. PEA research discovered that Palmitoylethanolamide binds to the peroxisome proliferator-activated receptor (PPAR-α) in the nucleus of cells. This particular receptor is responsible for regulating gene networks linked to pain control.

Another element that makes Palmitoylethanolamide unique is that it also has an affinity for cannabinoid-like receptors GPR55 and GPR119. Yet, PEA has no affinity for the classic cannabinoid receptors CB1 and CB2, so PEA does not carry the psychoactivity typically seen in classic cannabinoids.

Palmitoylethanolamide may also help regulate the expression of cyclooxygenase-2 (COX-2) as well as inducible nitric oxide synthase (iNOS). Research has found that COX-2 levels are elevated during periods of pain and inflammation. Interestingly, the expression of these proinflammatory molecules was also discovered in cases of neuroinflammation. The impact on inflammation, specifically Palmitoylethanolamide interactions with COX-2 and iNOS suggest that PEA may also support cognitive function. Findings also suggest that PEA may help regulate IkB-alpha degradation and p65 NF-kappaB nuclear translocation, due to its PPAR-alpha agonism. Studies have indicated that Palmitoylethanolamide’s action performs several biological functions that may help support pain mana

WHAT IS PALMITOYLETHANOLAMIDE?

Often abbreviated as PEA, Palmitoylethanolamide is a natural substance found in the body that may support pain management. Palmitoylethanolamide (PEA) was discovered in 1957 and it was referred to as N-(2-hydroxyethyl)-palmitamide at the time. Let's take a closer look at this intriguing natural molecule.

WHAT IS PALMITOYLETHANOLAMIDE?

Often abbreviated as PEA, Palmitoylethanolamide is a natural substance found in the body that may support pain management. Palmitoylethanolamide (PEA) was discovered in 1957 and it was referred to as N-(2-hydroxyethyl)-palmitamide at the time. Let's take a closer look at this intriguing natural molecule.

WHY CHOOSE PEA AS YOUR PAIN MANAGEMENT SUPPLEMENT OF CHOICE?

PEA is an endogenous fatty acid amide, and a member of the N-acetyl-ethanolamine family. Fatty acid amides are created from a combination of a fatty acid and an amine. Fatty acid amides are widely circulated in the body, and have a key role in biochemical signalling. Although PEA is an endogenous compound found throughout the human body, Palmitoylethanolamide can be found in foods too. The most common Palmitoylethanolamide food sources are milk and eggs. However, Palmitoylethanolamide is only present in these foods at trace amounts and does not promote significant PEA benefits.

Interestingly enough, hypersensitivity to pain is associated with a large decrease in PEA levels in the brain and spinal cord, areas directly and indirectly involved in protecting the nervous system from potentially harmful stimuli. This seems to indicate that PEA may be vital in bodily responses to pain. PEA research discovered that Palmitoylethanolamide binds to the peroxisome proliferator-activated receptor (PPAR-α) in the nucleus of cells. This particular receptor is responsible for regulating gene networks linked to pain control.

Another element that makes Palmitoylethanolamide unique is that it also has an affinity for cannabinoid-like receptors GPR55 and GPR119. Yet, PEA has no affinity for the classic cannabinoid receptors CB1 and CB2, so PEA does not carry the psychoactivity typically seen in classic cannabinoids.

Palmitoylethanolamide may also help regulate the expression of cyclooxygenase-2 (COX-2) as well as inducible nitric oxide synthase (iNOS). Research has found that COX-2 levels are elevated during periods of pain and inflammation. Interestingly, the expression of these proinflammatory molecules was also discovered in cases of neuroinflammation. The impact on inflammation, specifically Palmitoylethanolamide interactions with COX-2 and iNOS suggest that PEA may also support cognitive function. Findings also suggest that PEA may help regulate IkB-alpha degradation and p65 NF-kappaB nuclear translocation, due to its PPAR-alpha agonism. Studies have indicated that Palmitoylethanolamide’s action performs several biological functions that may help support pain relief.

WHAT YOU SHOULD KNOW ABOUT PALMITOYLETHANOLAMIDE

Sold out

PALMITOYLETHANOLAMIDE BENEFITS

PEA BENEFITS

Pain Management

Pain Management

Cognitive Support

Cognitive Support

Inflammation Support

Inflammation Support

Immune Health

Immune Health

PALMITOYLETHANOLAMIDE AND ENDOCANNABINOIDS

Although it isn’t technically an endocannabinoid, PEA often gets bundled into the cannabinoid family; particularly with anandamide, since PEA operates through similar synthetic and metabolic pathways. Endocannabinoids are compounds that naturally exist in our bodies, which interact with cannabinoid receptors. Both humans and animals naturally synthesize endocannabinoids that play a key role in bioregulation. They are mainly involved in cell signaling; producing same cell (autocrine) and cell-to-cell (paracrine) actions rather than full systemic effects.

The two notable cannabinoid receptors that PEA binds to are known as GPR55 and GPR119. These are G protein-coupled receptors found throughout the human body and brain. The GPR55 receptor is activated by endogenous cannabinoids such as anandamide (AEA). The GPR55 receptor was first discovered in 1999, and many started calling it the CB3 receptor.

Since both PEA and anandamide bind to the GPR55 receptor, supplementing PEA not only leads to the effects modulated by direct binding to the GPR55 receptor, but also leads to increased binding of anandamide to the CB1 and CB2 receptors. This happens since PEA competes for the GPR55 receptor with AEA. thus allowing more anandamide to become available to bind to the other cannabinoid receptors. The GPR119 receptor is another G protein-coupled receptor expressed mostly in the pancreas and gastrointestinal tract. GPR119 receptor activation has been shown to cause a reduction in food intake and reduction in body weight in rats.

PEA is an endogenous modulator and, as mentioned, it’s already present in many of the foods you already consume, albeit in trace amounts. In addition, its novel binding sites make it a unique possible solution for those looking for a supplement that may help promote balanced inflammation levels.

PALMITOYLETHANOLAMIDE BENEFITS

Although it is most well known for its ability to support pain management, here’s a list of other potential Palmitoylethanolamide benefits:

      • May Help Support Pain Management
      • May Help Promote Cognitive Function
      • May Help Support Balanced Inflammation Levels
      • May Help Promote Cardiovascular Function
      • May Help Support Immune Function

As can be seen above, Palmitoylethanolamide benefits are quite diverse! Better yet, Palmitoylethanolamide has been incredibly well studied over the last few decades, giving us unrivaled insight into the effect of these unique compounds.

As we mentioned above, PEA is most well known for its effects on pain, however, research has also found that a Palmitoylethanolamide supplement may help support cardiovascular function. Rodent research has found that Palmitoylethanolamide promoted cellular function and overall cell proliferation, particularly around heart tissue. These findings also revealed lower cytokine levels.

The unique effects profile of Palmitoylethanolamide however does not stop at pain management and cardiovascular support, because believe it or not, there is even evidence that indicates Palmitoylethanolamide benefits brain health! It appears to do this through the role it plays with neuroinflammation and its interaction with PPAR-α receptor. By balancing neuroinflammation, and through its effects on PPAR-α receptors, a Palmitoylethanolamide supplement may exert a positive effect on cognitive function. This pro-cognitive effects may even extend into promoting feelings of well being!

Palmitoylethanolamide Immune System Effects

PEA has even been shown to help support immune function, which is why we included it in our highly comprehensive Immune Defense formula.

In fact, one of the original uses of Palmitoylethanolamide was to minimize sick time. Several trials during the 1970s were conducted to evaluate PEA’s effects on our immune system. Interestingly enough, results determined that the use of PEA significantly supported immune system function.

Studies found that Palmitoylethanolamide may also help stabilize mast cells, which play a role in allergies. Palmitoylethanolamide has also demonstrated some ability to strengthen the immune system and also been shown to help speed up recovery from sickness.

Palmitoylethanolamide is a remarkable compound with several potential benefits and positive mechanisms within the body and brain. Ongoing PEA research aims to discover additional Palmitoylethanolamide benefits. If you’re thinking about adding PEA to your nootropic regimen, Nootropics Depot offers PEA as both a powder for customized dosing and as an easy to take 400mg capsule.

HOW TO TAKE PEA

Unlike some other supplements, Palmitoylethanolamide takes a few weeks to build up in our bodies, so certain effects may not be noticeable right away. The effects that are the most time-dependent with PEA are it’s pain support effects. However, don’t let this discourage you, as a lot of people have great success with PEA after giving it 2-4 weeks to build up in their bodies. This means that taking PEA consistently is the only way to ensure that your body is maximizing the potential Palmitoylethanolamide benefits.

STACKS WITH PEA

PEA has a versatile range of benefits and goes great with a lot of our other products. Here are 3 of our recommended PEA stacks!

PAIN MANAGEMENT SUPPORT STACK

Sold out

Sold out

PEA and Longvida provide inflammation support through two different pathways, making this a great, well-rounded combination for those looking to support pain management and balanced inflammation levels. The addition of Longvida Curcumin will also ensure quicker pain management effects, as its effects take hold much quicker than PEA.

IMMUNE HEALTH SUPPORT STACK

Sold out

Sold out

PEA and Turkey Tail have both demonstrated themselves as potent immune system supporters. As a combo, PEA and Turkey Tail mushroom may help bolster your immune system.

COGNITIVE SUPPORT STACK

Sold out

Sold out

PEA’s impact on inflammation paired with Chaga’s ability to promote balanced oxidation levels work together nicely to support cognitive function and overall brain health. This combination may help cut through the daily fog, allowing you to dial in your focus.

Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

READ MORE NOOTROPICS DEPOT BLOGS

TeaCrine: A Detailed Guide To This Long-Lasting Theacrine Supplement For Energy And Focus

MicroMag: A Novel and Highly Bioavailable Magnesium Supplement

The Ultimate Guide to the Best Mushroom Extracts

Injuv®: A Clinically-Studied Hyaluronic Acid Supplement For Youthful Looking Skin

Kaneka Ubiquinol: Introducing A Bioavailable and Crystal-Free Reduced CoQ10 Supplement

Chocamine: A Cocoa Extract For Memory, Focus, and Concentration

The Top Benefits of Polygala tenuifolia

The Top Benefits of Lemon Balm

The Top Benefits of Uridine

The Top Nootropic Mushroom Extracts

The Top Benefits of Gotu Kola Extract

The Top Benefits of L-Theanine

The 5 Best Sleep Supplements That Aren't Melatonin

The Best Supplements for Collagen Synthesis

Dynamine Methyllberine For Energy, Mood, and Motivation

The Top Benefits of Ashwagandha

CoQSol-CF: The Superior CoQ10 Supplement

The Top Benefits of Milk Thistle

The Top Benefits of Taurine

Did You know Your Melatonin Supplement May Be Overdosed?

The Top 5 Immune Supplements

EpiCor: The Immune Supplement You May Not Know About

The Top Benefits Of Black Seed Extract

Magnesium Glycinate vs. Magnesium L-Threonate: Which Is The Best For You?

Cognizin Citicoline for Healthy Brain Function

The Top Benefits for 7,8-DHF

Creatine As Nootropic

What You Need To Know Before You Buy A Curcumin Supplement

Comparing Rhodiola Rosea and Crenulata Extracts

The Top Benefits of Berberine

Lion's Mane Mushroom: Comparing Our 1:1 and 8:1 Extracts

Nitric Oxide Boosters Compared: L-Citrulline vs. Agmatine vs. AAKG

Red Reishi Mushroom: Comparing Our 1:1 and 8:1 Extracts

The Top Anti-Aging Supplements

Cordyceps militaris: Comparing Our 1:1 and 10:1 Extracts

Bacopa monnieri: Bacognize vs. Synapsa

The Nootropic Synergy of Caffeine and L-Theanine

L-Citrulline vs. L-Citrulline DL-Malate

A Look At PrimaVie Shilajit Extract

A Look At Nootropics Depot's Purity Testing

The Ultimate Guide to Choline Supplements

The Ultimate Guide to Fish Oil Supplements

Palmitoylethanolamide And Its Pain Management Benefits

The Ultimate Guide to Adaptogen Supplements

The Ultimate Guide to Mushroom Extracts

What You Might Not Know About Panax Ginseng

Ashwagandha: KSM-66 vs. Sensoril

Teacrine: A Natural Alternative To Caffeine

About Nootropics Depot

Nootropics Depot is an online-based vendor of high quality nootropics, novel plant extracts, amino acids, fish oil, choline supplements, vitamins, and more based in Tempe Arizona. We were founded in 2013 when we realized the industry needed a trusted source for these products and someone to champion the change the supplement industry needs. We have our own in-house analytical testing lab with some of the best analytical chemists in the supplement industry. We are constantly striving to advance and improve the purity and analytical standards of not only the nootropics industry, but the larger supplement industry as a whole.