About Relievex Capsules

Relievex is a comprehensive relaxation and Pain and Inflammation support supplement that combines eight targeted ingredients to address muscle tension and discomfort. The blend features kava extract, lemon balm extract, and micronized palmitoylethanolamide alongside our exclusive tetrahydromagnolol. Unlike traditional inflammation-focused supplements, Relievex targets the GABAergic and cannabinergic systems to promote deep muscle relaxation while maintaining mental clarity during daytime use.

Our Relievex Story

Over the years, we discovered a significant gap in natural pain management solutions. While inflammation-based pain responds well to botanicals like Andrographis paniculata and Longvida, muscle knots, tension, and nerve related pain proved much more challenging to address effectively. We had been creating personal stacks for ourselves, friends, and family with remarkable success, which gave us the anecdotal data needed to develop a comprehensive solution.

Our breakthrough came from focusing on muscle relaxation pathways rather than just inflammation control. Relievex targets both GABAergic and cannabinergic systems, which play crucial roles in pain perception and physical tension. By combining proven ingredients like ginger extract and maca extract with our proprietary tetrahydromagnolol, we created a formula that produces deep muscle relaxation while supporting Mood and maintaining functional energy levels throughout the day.

Benefits

• Supports Pain Management: Relievex targets difficult pain types like muscle knots and tense muscles through the GABAergic and cannabinergic systems, with micronized palmitoylethanolamide providing particularly strong support for nerve related pain.
• Balances Inflammation Levels: Ginger extract and supercritical CO2 boswellia extract work together to support healthy inflammatory responses while creating a warm, soothing sensation throughout the body.
• Supports Sleep: The blend promotes deep physical relaxation through GABA receptor activation from kava extract and GABA elevation via lemon balm extract, making it easier to fall asleep when discomfort keeps you awake.
• Supports Mood Elevation: Relievex produces a unique mood-boosting effect by combining physical relaxation with mental clarity, creating a profound sense of calm that takes the edge off during stressful periods without inducing lethargy.

The formula includes maca extract to provide gentle mental energy while maintaining deep physical relaxation, and tetrahydromagnolol, an exclusive compound that enhances CB2 receptor activity for additional pain modulation support. This combination allows Relievex to remain functional for daytime use while providing the flexibility to increase the dose for more pronounced evening relaxation.

Quality and Standardization

• Multi-Component Standardization: We standardize each of the eight ingredients in Relievex to precise specifications, including our kava extract at 30% kavalactones and micronized PEA for optimal bioavailability.
• Advanced Extraction Methods: Our supercritical CO2 boswellia extraction specifically targets TRPV3 receptor activation while our proprietary tetrahydromagnolol represents a unique hydrogenated form of magnolol found nowhere else in the supplement industry.
• Comprehensive Laboratory Testing: Every batch undergoes rigorous testing for purity, potency, and identity verification through our third-party labs to ensure consistent therapeutic effects across all eight synergistic compounds.
• Bioavailability Enhancement: We include piperine extract based on extensive user feedback comparing formulations with and without this absorption enhancer, consistently demonstrating superior effectiveness in the final blend.

Mechanism of Action

• GABAergic System Enhancement: Kava activates GABA receptors directly while lemon balm extract inhibits GABA transaminase, the enzyme that breaks down GABA into glutamate, creating a dual pathway for enhanced GABAergic activity and deep muscle relaxation.
• Cannabinoid System Modulation: Micronized palmitoylethanolamide acts as an endocannabinoid while maca extract inhibits fatty acid amide hydrolase (FAAH), preventing endocannabinoid breakdown and amplifying the body's natural pain regulation pathways.
• CB2 Receptor Targeting: Tetrahydromagnolol, created through hydrogenation of magnolol, demonstrates significantly stronger CB2 receptor agonism than its parent compound, specifically targeting pain modulation without the psychoactive effects associated with CB1 activation.
• Vanilloid Receptor Interaction: Ginger extract modulates vanilloid receptors to reduce pain perception while our supercritical CO2 boswellia extract activates TRPV3 receptors, creating a warming sensation that promotes muscle relaxation through thermoreceptor pathways.
• Bioavailability Enhancement: Piperine works through multiple mechanisms including inhibition of drug-metabolizing enzymes and increased intestinal absorption, ensuring optimal uptake of all eight active compounds in this stress and pain management formula.

Overview of the Science

Research demonstrates that Relievex's targeted ingredients work through multiple pathways to support the body's natural pain management systems. Palmitoylethanolamide (PEA) has shown significant promise in clinical studies for pain support, with meta-analyses revealing consistent benefits for both chronic and acute discomfort [1][2]. The endocannabinoid compound works particularly well for nerve-related pain by modulating pain perception at the cellular level. Meanwhile, our standardized kava extract provides kavalactones that interact with both GABA and cannabinoid CB1 receptors, creating a dual pathway for physical and mental relaxation.

The inclusion of tetrahydromagnolol represents cutting-edge research into cannabinoid receptor modulation. Studies indicate that magnolia-derived compounds activate cannabinoid CB2 receptors while demonstrating anti-inflammatory properties [3]. Our proprietary hydrogenation process creates tetrahydromagnolol, which shows enhanced CB2 receptor binding compared to standard magnolol. This selective CB2 activation supports pain modulation without the psychoactive effects associated with CB1 receptor activity. Additionally, clinical research on andrographis compounds supports their role in managing inflammatory responses, with controlled trials showing significant benefits for joint comfort and mobility [4][5].

The synergistic combination creates effects that individual ingredients cannot achieve alone. Lemon balm's GABA-T inhibition elevates natural GABA levels while maca's FAAH inhibitory macamides preserve endocannabinoids, creating sustained activity throughout the day. Research on magnolia compounds confirms their analgesic properties in both acute and inflammatory pain models [6]. This multi-target approach addresses the complexity of pain perception by supporting natural neurotransmitter balance, endocannabinoid function, and inflammatory response pathways simultaneously. The addition of piperine enhances bioavailability across all active compounds, ensuring optimal absorption for maximum benefit.

[1] Lang-Illievich K, Klivinyi C, Lasser C, Brenna CTA, Szilagyi IS, Bornemann-Cimenti H. Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials. Nutrients. 2023;15(6):1350.

[2] Artukoglu BB, Beyer C, Zuloff-Shani A, Brener E, Bloch MH. Efficacy of Palmitoylethanolamide for Pain: A Meta-Analysis. Pain Physician. 2017;20(5):353-362.

[3] Rempel V, Fuchs A, Hinz S, Karcz T, Lehr M, Koetter U, Müller CE. Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55. ACS Med Chem Lett. 2013;4(1):41-5.

[4] Burgos RA, Hancke JL, Bertoglio JC, Aguirre V, Arriagada S, Calvo M, Cáceres DD. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Clin Rheumatol. 2009;28(8):931-46.

[5] Gupte PA, Giramkar SA, Harke SM, Kulkarni SK, Deshmukh AP, Hingorani LL, Mahajan MP, Bhalerao SS. Evaluation of the efficacy and safety of Capsule Longvida® Optimized Curcumin (solid lipid curcumin particles) in knee osteoarthritis: a pilot clinical study. J Inflamm Res. 2019;12:145-152.

[6] Lin YR, Chen H, Ko CH. Effects of honokiol and magnolol on acute and inflammatory pain models in mice. Life Sci. 2007;81(15):1071-8.

Ingredients