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Posted by Nootropics Depot on September 06, 2018
Not every form of choline readily makes it into the brain. However, Cognizin Citicoline has been found to rapidly make its way into the brain after supplementation. Once in the brain, choline itself can act on a very important cholinergic receptor: the alpha-7 nicotinic acetylcholine receptor. This is one of the main cholinergic receptors involved with cognitive function, and activation of this receptor has been shown to lead to fairly profound cognitive support. Furthermore, the choline from Cognizin Citicoline is rapidly converted to acetylcholine. You can learn more about this process below.
What sets Cognizin Citicoline apart from other choline sources is its unique composition. Citicoline consists of phosphocholine and cytidine. Upon consumption, the phosphocholine and cytidine separate and the cytidine promptly turns into uridine. Uridine is a unique molecule that interacts with both the cholinergic and dopaminergic systems of the brain. Phosphocholine is also unique, in that it helps with the synthesis of a molecule called phosphatidylcholine, which is an important component of neuronal membranes. Therefore, supplementation of Cognizin Citicoline not only supports brain function with readily available choline, it also supplies it with uridine and phosphocholine which all have additive benefits in terms of overall brain health and cognition.
To learn more about Cognizin Citicoline research, see the infographic below.
Anyone looking for subtle support in brain function should consider supplementing Cognizin Citicoline, especially if their dietary choline intake is low. It has been found that choline deficiencies are surprisingly common these days, and thus consuming some extra choline is always a good idea. This is especially true for high bioavailability choline sources such as Cognizin Citicoline, which can promote benefits to both the brain and body.
Cognizin Citicoline is especially beneficial for individuals who are currently using supplements that optimize the cholinergic system, as Cognizin Citicoline may enhance their effects. For example, Acetyl L-Carnitine and Cognizin Citicoline may complement each other’s mechanism of action. This is due to the fact that Acetyl L-Carnitine enhances the rate at which acetylcholine is synthesized. It does this by increasing levels of coenzyme acetyl COA, and by enhancing the efficiency of the choline acetyl transferase enzyme. By taking them together, we have more available choline in addition to more available coenzyme acetyl COA. Acetyl L-carnitine also appears to affect a process called high affinity choline uptake (HACU). HACU is the process by which choline is pulled into cholinergic neurons where it can be turned into acetylcholine. As the cherry on top, Acetyl L-Carnitine also appears to enhance acetylcholine release from cholinergic neurons. Taking everything together, Acetyl L-Carnitine and Cognizin Citicoline go hand in hand to support brain function. This is just one example, however, and Cognizin Citicoline goes well with a plethora of other brain health supplements that interact with the cholinergic system.
Kyowa is an international health ingredient manufacturer and a world leader in the development, manufacturing and marketing of nutraceuticals, pharmaceuticals and food products. Kyowa is dedicated to ongoing scientific research, quality management and consumer education.
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Choline is an essential nutrient that is found in a variety of foods; with one of the highest choline food sources being eggs. Choline has a lot of effects throughout the body and brain. Choline is an important intermediary molecule when it comes to methylation. Choline is converted to trimethylglycine in the the mitochondria of cells, and trimethylglycine is one of the main methyl donors in our bodies. This supports our liver health as well as a wide array of bodily functions, including promoting healthy cardiovascular function (by supporting homocysteine levels) and a positive mood (by supporting SAMe levels).
Choline, besides getting converted to trimethylglycine, can also be converted to acetylcholine, an important neurotransmitter. Choline reacts with coenzyme acetyl-COA, which via an enzyme called choline acetyltransferase results in a transfer of an acetyl group from coenzyme acetyl-COA to choline. Acetylcholine regulates many functions both in our bodies and brains. One of the most prominent functions of acetylcholine is that it regulates muscle contractions. As a thought experiment, clench your hand into a fist and then relax it again. This seems like a very simple task. However, if we look at this from a molecular biology standpoint, this task turns out to be fairly complex and delicate. Below is a brief description of how acetylcholine participates in contracting your muscles to form a fist:
1. A signal from your brain travels down nerve pathways into your hand
2. This signal triggers the release of acetylcholine at the neuromuscular junction
3. The acetylcholine attaches to nicotinic receptor on smooth muscle fibers, causing the muscles in your hand to contract in order to form a fist
4. The acetylcholine releases from the receptor and is cleared out by an enzyme called acetylcholinesterase, this causes your clenched fist to relax again.
This is a very delicate process because there has to be an on/off switch for relaxing and contracting your muscles. This on/off switch is largely dependent on the release and clearance of acetylcholine. It has been found that inhibiting the acetylcholinesterase enzyme to a certain degree may promote cognitive function. This has sparked a wide array of research into the function of acetylcholine in the brain. What has been found is that acetylcholine supports a wide array of neurological functions such as mood, memory, learning, perception, sleep and wakefulness. Therefore, promoting acetylcholine levels in the brain may lead to support of overall brain health and cognitive function.
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