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Creatine: A Nootropic for Bodybuilders, Athletes, Vegans, and Vegetarians

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Creatine - A Nootropic Supplement for Bodybuilders, Athletes, Vegans, and Vegetarians

What Is Creatine?

Creatine is an important molecule that is produced by our bodies and consumed through our diet. creatine turns into phosphocreatine in the body, and phosphocreatine is able to store and release energy in the form of phosphate groups. Through this mechanism, creatine monohydrate powers many important processes throughout the body. Most notable is that creatine is necessary for proper functioning of our muscles and brains. In addition to this, creatine also helps hydrate our cells. This not only enhances the function of our cells but protects them too!

What Does Creatine Do?

Due to the fact that creatine powers so many different processes throughout the body, it has a lot of different use cases. Athletes can use it to enhance their performance. Students can use it to enhance memory under stressful conditions. Vegetarians and vegans can even use it to support their overall brain health! In general, it is a very versatile molecule and most people can benefit from consuming a little bit more creatine. This is mainly due to the fact that, besides beef, there aren’t many foods that are high in creatine. In addition to this, synthesizing creatine in the body is a fairly taxing process and not very much of it is made. This makes it especially important for vegetarians and vegans to consider a creatine supplement. Which brings us to our next point, what creatine supplement is the best?

Forms of Creatine

Due to the fact that creatine is incredibly popular in athletic applications, there has been a big push to develop improved versions of the most basic form of creatine, creatine monohydrate. One limitation of basic creatine monohydrate is that it has limited water solubility. This has proven to be somewhat of a limitation when it comes to bioavailability. That being said, this can easily be overcome by supplementing with larger doses of creatine monohydrate. Another method to overcome this is by producing different salts of creatine which are more water soluble. One of these salts is creatine hydrochloride which is significantly more water soluble.

However, creatine hydrochloride is also much more expensive, incredibly sour and it doesn’t have a whole lot of supporting evidence behind it. There are also other forms which aim to enhance bioavailability by producing creatine salts that can be absorbed by transporters other than the creatine transporter. Notable examples include creatine gluconate and creatine ascorbate. In theory, these other salts should all offer benefits above and beyond creatine monohydrate, however, this does not seem to be the case. Most salts of creatine, besides creatine monohydrate, do not have a lot of high quality scientific evidence on them. In fact, some don’t have any research on them at all. Another issue, is that they often have off-putting flavors and are significantly more expensive. Based on this, and the high quality of scientific evidence behind creatine monohydrate, creatine monohydrate should always be the default choice when considering creatine supplementation.

Creatine Monohydrate

Creatine Monohydrate Structure

Creatine Monohydrate Structure

Molecular Formula: C4H11N3O3

Molecular Weight: 149.15 Daltons 

Hydrogen Acceptor Count: 4

Hydrogen Donor Count:

LogP: -1.6 

Lipinski’s Rule of Five: Yes 

Dosage: 5,000 mg, once per day 

Solubility: 4.11 mg/mL 

Visual: White fluffy powder 

Smell: No smell 

Taste: Tasteless

Buy Creatine Monohydrate  

Strength and physical benefits of Creatine Supplements

The most common use for creatine monohydrate is to enhance physical performance. Studies have shown that creatine monohydrate supplementation can significantly enhance various parameters of exercise performance, such as strength and speed. The mechanism by which this works is mainly through acting as a buffer for adenosine triphosphate (ATP). ATP is one of the main energy molecules in our body. It powers all of our cells and in turn is responsible for nearly all of our bodily functions, including muscle performance.

The way ATP works is that if energy is needed somewhere in the body, one of the three phosphate groups in ATP will be broken off through a process called hydrolysis. Once this happens, energy is released and the ATP is converted to adenosine diphosphate (ADP). This release of energy allows us to contract our muscle. The more contraction we require of our muscles, such as if we were riding a bike or lifting weights, the more ATP we require. This is where creatine monohydrate comes in. Think of ADP like a dead battery and ATP like a fully charged battery. creatine monohydrate helps recharge the dead battery (ADP) by adding a phosphate group to it. It does this by increasing phosphocreatine stores in cells with high-energy demand, such as in muscle tissue and in the brain. Phosphocreatine can then help rapidly re-synthesize ATP from ADP by adding an additional phosphate group to ADP, leading to more overall available energy.

Creatine ATP to ADP Diagram

So, by supplementing creatine monohydrate, our muscles have more access to ATP which means that they can contract harder and faster. This is ultimately what causes the strength and speed increases seen with creatine monohydrate supplementation.

Creatine Loading: How Much Creatine Should I Take?

When it comes to strength application of creatine monohydrate, a loading phase is often times recommended. A loading phase is when creatine monohydrate is taken at a higher dosage of 20 grams per day for the first five to seven days of supplementation. The theory behind this, is that your creatine phosphate stores will increase more rapidly, which theoretically should produce strength benefits at a faster rate. This comes at the trade off of gaining a lot of water weight in a short amount of time. Some people can gain up to 5 pounds in water weight during the loading phase. This is because creatine monohydrate acts as an osmolytic. Osmolytics draw water into cells to hydrate them. This is also another mechanism by which creatine monohydrate helps enhance exercise performance. That being said, with an abundance of creatine monohydrate during a loading phase, our cells will absorb and hold a lot of water. Regular creatine monohydrate supplementation will also do this, but at a slower pace and to a much lower extent.

Interestingly enough, it appears that high dosages of creatine display impaired bioavailability. This is dependent on the water solubility of creatine monohydrate. Large doses, as seen in the creatine loading phase, will cause an accumulation of undissolved creatine monohydrate in the intestinal lumen. This means that taking the loading phase dose all at once will be counterproductive. A way around this would be to take smaller dosages of creatine monohydrate at different points throughout the day until you reach the 20-gram mark. This, however, will still lead to rapid water weight gain. This leaves us with the question, is creatine loading necessary?

In our opinion, the benefits of creatine loading are not worth the hassle and rapid water weight gain. Just starting creatine monohydrate supplementation at the recommended 5-gram dose is the best dosage regimen. This dosage will produce results slightly slower than loading creatine, however, it will still work just as well. In addition to this, the loading phase is often also associated with having to cycle on and off of creatine monohydrate. The cycling of Creatine monohydrate is also associated with having to redo the loading phase at the start of each creatine cycle. With the daily 5-gram dose, there is no need to cycle and this dosage can just be taken indefinitely.

Cognitive Benefits of Creatine Supplementation

A lot of the cognitive benefits of creatine monohydrate supplementation can be traced back to the ATP system. Similar to muscles, most processes in our brain require ATP. Thus, by increasing phosphocreatine stores in the brain, various brain processes will be running faster and better. This should support an overall increase in brain function. To get more specific, ATP is also very important in regulating calcium influx into glutamate neurons. Calcium is very important to the functioning of glutamate neurons, however, it can also overexcite glutamate neurons. This excitation is normally mitigated by the sodium-potassium ATPase pump, by pumping excess calcium out of the neuron. As the name suggests, this pump is dependent on ATP, and if ATP levels are low, calcium will start to accumulate in the neuron. Once calcium levels are too high, the neurons will get overexcited to the point that it dies. This process is called excitotoxicity and is a major threat to cognitive function. By elevating ATP levels in critical areas of the brain, creatine monohydrate can prevent this from happening. Through this process, creatine monohydrate protects the brain and in turn helps promote healthy cognitive function.

ATP Structure

Going a little more in depth in the glutamate system, creatine monohydrate is also able to enhance the activity of a specific glutamate receptor called the NMDA receptor. Activation of this receptor sets in motion a process called long term potentiation (LTP). LTP is one of the processes by which our brain encodes memories, and thus LTP is a crucial process when it comes to cognitive function. Creatine, by enhancing NMDA receptor function, has the potential of boosting LTP. The problem however, with enhanced NMDA receptor function is that it can also lead to excitotoxicity. Luckily, creatine has been shown to be neuroprotective against glutamate and H2O2 toxicity!

Creatine monohydrate also has the ability to support dopamine levels and dopaminergic neurons. This effect in addition to its protective effects on the glutamatergic system, make it a very versatile neuroprotective supplement. Taken together, the protective effects of creatine paired with enhanced NMDA receptor function and improved ATP production, make it a very interesting option for overall cognitive support. This being said, the effects of creatine on cognition, by itself, are not very significant and most people will not notice a very large boost in cognitive performance from just creatine monohydrate. However, it does go very well with a plethora of other compounds to support their effects. To see some ideas of how to use creatine monohydrate in conjunction with other compounds, please see the end of this blog where we give three examples of three different nootropic stacks that incorporate creatine monohydrate.

There is however an exception to the rule. If you are currently following a vegan or vegetarian diet, then creatine monohydrate supplementation may produce much more noticeable cognitive effects. We will discuss this in more detail in the following section:

Should Vegans Take Creatine?

Due to the fact that one of the most abundant sources of creatine is found in beef, vegans and vegetarians run the risk of creatine deficiency. In fact, since creatine is a major player in cognition, vegans and vegetarians may need additional support for their cognitive function. Various studies have indicated that when it comes to cognition, vegans and vegetarians benefit significantly more from creatine supplementation than people who are not vegan and vegetarian. 

For athletes that are vegan or vegetarian, creatine could also significantly support exercise performance. This again, is based on the fact that vegans and vegetarians appear to be somewhat deficient in creatine. This means that they will likely experience even greater physical benefits than people who are not vegan or vegetarian. In addition to this, the extra cognitive edge could also help enhance sports performance.

Using Creatine as a Nootropic

Since creatine has the ability to safely support overall cognitive function long-term, it perfectly fits the classic criteria of what a nootropic should be. These criteria were defined by Romanian chemist Corneliu E. Giurgea who coined the term nootropic. Below are his criteria which qualify a compound for being a nootropic:

1. Nootropics need to be able to help support learning and memory

2. Nootropics should help support cognitive function from physical stressors

3. Nootropics should be neuroprotective

4. Nootropics should support overall brain function

5. Nootropics should be very safe and have extremely low toxicity.

In addition to this, they should lack any prominent psychoactive effects

As can be seen from the list above, creatine monohydrate complies to all criteria. It appears to reliably preserve and even enhance learning and memory. It appears to be neuroprotective, protecting from various physical and chemical insults. Creatine supports the central nervous system by optimizing energy processes in the brain and it lacks any profound psychoactive effects.

Based on the above and the supportive, rather than directly enhancing, effects of creatine on brain function - it is a great supplement to take alongside other nootropics.

Creatine in a Nootropic Stack

Below are three simple stacks which incorporate creatine and two other ingredients. These are designed to get the most out of every single ingredient by focusing on Creatine monohydrate to support brain function...

The NMDA receptor support stack:

Creatine Monohydrate

Magnesium Glycinate

KSM-66 Ashwagandha

The brain energy support stack:

- Creatine Monohydrate

Na-R-ALA or Cyclodextrin ALA

- Coenzyme Q10 or CoQsol CF

The neuroprotection stack:

- Creatine Monohydrate


Pomella pomegranate extract

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