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Green Tea: A Natural Plant Extract High in EGCG Content For Our Brain, Mood,  and Metabolic Health

Green Tea: A Natural Plant Extract High in EGCG Content For Our Brain, Mood, and Metabolic Health

Posted by Nootropics Depot on 20th May 2020

GREEN TEA EXTRACT WITH 45% EGCG

Camellia sinensis, better known to us as tea and the source of many different varieties of tea, is a treasure trove of unique bioactive molecules! What is often somewhat poorly understood, is that oolong tea, black tea, green tea, matcha tea, white tea, pu’erh tea and even kukicha tea are all the same species of tea: Camellia sinensis. The difference between all of these different types of tea is that they are processed and grown differently. For example, the only difference between black and green tea is that black tea has been oxidized whereas green tea has not. This oxidization process has a major impact on the flavor, aroma and appearance of Camellia sinensis leaves. These changes in aroma and appearance also correspond to chemical changes.

Unprocessed, raw Camellia sinensis leaves produce a collection of compounds called ‘Catechins’ which are flavan derivatives that contain a 2-phenyl-3,4-dihydro-2H-chromen-3-ol skeleton. The four main catechins that are present in Camellia sinensis leaves are:

- Epigallocatechin-3-gallate
- Epigallocatechin
- Epicatechin gallate
- Epicatechin

In Green Tea, all of the above flavan derivatives are preserved due to the minimal amount of processing involved with Green Tea production. However, during the processing of black teas, something very interesting happens! Camellia sinensis leaves contain a compound called polyphenol oxidase (PPO), which is released during the maceration and fermentation stage of black tea processing. This enzyme, in tandem with pH changes that occur during fermentation, turn the flavan derivatives into Theaflavins and Thearubigins. These two compounds give black tea its characteristic taste, aroma and appearance but it also significantly changes the effects profile! Both the flavan derivatives found in Green Tea and the theaflavins found in black tea both have excellent bioactivities. A standout, however, is Epigallocatechin-3-gallate (EGCG), which is found in high concentrations in Green Tea.

GREEN TEA EXTRACT WITH 45% EGCG

Camelia sinensis, better known to us as tea and the source of many different varieties of tea, is a treasure trove of unique bioactive molecules! What is often somewhat poorly understood, is that oolong tea, black tea, green tea, matcha tea, white tea, pu’erh tea and even kukicha tea are all the same species of tea: Camellia sinensis. The difference between all of these different types of tea is that they are processed and grown differently. For example, the only difference between black and green tea is that black tea has been oxidized whereas green tea has not. This oxidization process has a major impact on the flavor, aroma and appearance of Camellia sinensis leaves. These changes in aroma and appearance also correspond to chemical changes.

GREEN TEA EXTRACT WITH 45% EGCG

Camelia sinensis, better known to us as tea and the source of many different varieties of tea, is a treasure trove of unique bioactive molecules! What is often somewhat poorly understood, is that oolong tea, black tea, green tea, matcha tea, white tea, pu’erh tea and even kukicha tea are all the same species of tea: Camellia sinensis. The difference between all of these different types of tea is that they are processed and grown differently. For example, the only difference between black and green tea is that black tea has been oxidized whereas green tea has not. This oxidization process has a major impact on the flavor, aroma and appearance of Camellia sinensis leaves. These changes in aroma and appearance also correspond to chemical changes.

Unprocessed, raw Camellia sinensis leaves produce a collection of compounds called ‘Catechins’ which are flavan derivatives that contain a 2-phenyl-3,4-dihydro-2H-chromen-3-ol skeleton. The four main catechins that are present in Camellia sinensis leaves are:

- Epigallocatechin-3-gallate
- Epigallocatechin
- Epicatechin gallate
- Epicatechin

Unprocessed, raw Camellia sinensis leaves produce a collection of compounds called ‘Catechins’ which are flavan derivatives that contain a 2-phenyl-3,4-dihydro-2H-chromen-3-ol skeleton. The four main catechins that are present in Camellia sinensis leaves are:

- Epigallocatechin-3-gallate
- Epigallocatechin
- Epicatechin gallate
- Epicatechin

In Green Tea, all of the above flavan derivatives are preserved due to the minimal amount of processing involved with Green Tea production. However, during the processing of black teas, something very interesting happens! Camellia sinensis leaves contain a compound called polyphenol oxidase (PPO), which is released during the maceration and fermentation stage of black tea processing. This enzyme, in tandem with pH changes that occur during fermentation, turn the flavan derivatives into Theaflavins and Thearubigins. These two compounds give black tea its characteristic taste, aroma and appearance but it also significantly changes the effects profile! Both the flavan derivatives found in Green Tea and the theaflavins found in black tea both have excellent bioactivities. A standout, however, is Epigallocatechin-3-gallate (EGCG), which is found in high concentrations in Green Tea.


WHAT IS EGCG?

RAs we discussed earlier in this article, EGCG is one of the major flavan derivatives in Camellia sinensis leaves, and can be found in high concentrations in Green Tea. With modern extraction techniques, we are able to isolate this compound from Green Tea leaves. This allows us to get enormous amounts of this compound into extracts, like our EGCG extract we are discussing in this blog, which contains a whopping 45% EGCG! So what makes EGCG so special, and so highly sought after?


WHAT DOES GREEN TEA EXTRACT DO?

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✔ MAY HELP SUPPORT BRAIN HEALTH

✔ MAY HELP SUPPORT BALANCED OXIDATION LEVELS

✔ MAY HELP SUPPORT SKIN HEALTH

✔ MAY HELP SUPPORT METABOLIC HEALTH

✔ MAY HELP SUPPORT A POSITIVE MOOD


GREEN TEA EGCG BENEFITS FOR BRAIN HEALTH

One of the most common Green Tea benefits is its ability to promote brain health via its EGCG content. It does this through a variety of pathways, two of the main pathways are through promoting balanced levels of oxidation and inflammation. Our brains are very sensitive to the effects of oxidative stress and inflammation, but luckily our brains are also very good at naturally regulating healthy oxidative and inflammatory responses. However, sometimes our brain needs an extra level of support, and this is where a Green Tea supplement may be useful.

The EGCG content in Green Tea supplements, especially a Green Tea extract that is standardized to high EGCG content, does a fantastic job of supporting a healthy balance of oxidation and inflammation in our brains. This will help not only support general brain health, but it will also help promote cognitive function. Green Tea supplements may also have much more interesting effects on brain health, so let's dive into some newly discovered cutting edge Green Tea benefits for brain health!

It has been found that the EGCG content in Green Tea supplements helps kick start a process in the brain called ‘neurite outgrowth’. This is a process by which neurons grow and form new connections. This helps promote brain health but also helps promote cognitive function. Interestingly enough though, EGCG only helps promote neurite outgrowth, yet it does not actually help promote neurite outgrowth. Looks like we have hit a dead end then? According to new research, it appears that EGCG levels become undetectable at a fairly rapid rate in the brain, so what’s happening to EGCG once it enters the brain? It appears that EGCG only has a brief moment to exert its effects in the brain, after which it becomes metabolized into other bioactive compounds. The EGCG metabolites appear to be able to actually promote neurite outgrowth, piggybacking on the neurite outgrowth induction that was initially produced by EGCG. This means that both EGCG and its metabolites may work hand-in-hand to promote neuritogenesis!


GREEN TEA EGCG BENEFITS FOR OXIDATIVE SUPPORT

As we briefly mentioned in the section above, Green Tea supplements have a very positive effect on helping to balance levels of oxidation throughout the body and brain. The oxidation-balancing effects of EGCG have long been a mystery, but recent research has uncovered some very interesting properties of EGCG.

All of the Green Tea Catechins have the ability to support balanced oxidation levels. They do this largely through their molecular structure, which allows them to donate electrons to free radicals. This helps neutralize free radicals, thereby helping to balance oxidation. The reason Green Tea catechins can do this, is due to the presence of hydroxyl groups in their molecular structure. EGCG has 8 hydroxyl groups, all lined up in just the perfect way, which allows EGCG the best efficacy as a free radical scavenger, amongst all of the other Green Tea Catechins. This is why we standardize for such a high amount of EGCG in our Green Tea supplements!

Furthemore, Green Tea EGCG also appears to be able to chelate various metals such as Iron, Copper, Chromium and Cadmium, which can all promote oxidative damage. By chelating these metals, EGCG may help support balanced levels of oxidation. This is a very minor effect in comparison to its other oxidation balancing effects, however. Furthermore, EGCG also appears to be able to promote superoxide dismutase (SOD) function. SOD is an enzyme which helps support balanced oxidation levels, and by enhancing SOD levels, EGCG may exert beneficial effects on oxidation.

"Research has shown that magnesium levels are decreasing in most foods... With the magnesium content decreasing in crops and the increase in the consumption of processed foods, magnesium deficiencies in the population are becoming more prevalent."


GREEN TEA EGCG BENEFITS FOR SKIN HEALTH

Green Tea supplements are also quite popular for skin health, and for very good reason! Our skin is sensitive to the effects of oxidation, and thus by balancing oxidation levels, EGCG has a direct positive effect on skin health. However, Green Tea supplements can go a step further via a very unique mechanism!

Green Tea supplements, through their EGCG content, may help regulate sebum production. This may lead to noticeably smoother and blemish free skin, in addition to the increased smoothness and plasticity of the skin due to EGCG’s oxidation balancing effects!

If you would like to learn more about how Green Tea supplements help promote skin health, we would like to invite you to read our skin health blog, which covers Green Tea, and its effects on skin, in much more detail!


GREEN TEA EGCG BENEFITS FOR METABOLIC HEALTH

Another interesting effect of Green Tea supplements is their ability to help promote metabolic function. This is also what Green Tea supplements are often most famous for, as they find their way into most common fat burning supplements. This is for good reason as Green Tea supplements have some very interesting effects on fat burning!

Green Tea supplements, mainly through their EGCG content, have the ability to regulate an enzyme called Catechol-O-Methyltransferase (COMT). One of the main functions of COMT is to break down catecholamines such as norepinephrine. By regulating COMT, Green Tea supplements have the ability to promote higher levels of these catecholamines in the body. This is important as higher levels of these catecholamines can signal our bodies to start burning fat. In particular, it appears that Green Tea supplements help further promote the fat burning effects of Caffeine. This is due to the fact that Caffeine also helps promote Catecholamine levels, but via different mechanisms than Green Tea supplements. This ultimately means that Caffeine and Green Tea supplements work together synergistically to promote Catecholamine levels and fat burning effects!


GREEN TEA EGCG BENEFITS FOR MOOD SUPPORT

Last but not least, Green Tea supplements may even help promote a positive mood! It does this through some pretty unique mechanisms. It appears that EGCG helps promote GABAergic function in the brain. It does this by primarily reversing negative modulation of GABAergic receptors, thereby helping to promote GABAergic activity. Furthermore, it appears that EGCG itself has the ability to promote GABAergic activity in the brain, which helps promote relaxation.

Furthermore, this calming EGCG effect has been shown to support stress management efforts! The combination of the stress-regulating and calming effects suggests that EGCG may actually help promote sleep quality. This is a unique attribute for high EGCG and low Caffeine Green Tea supplements like ours! A cup of Green Tea promotes a state of calm stimulation, due to the combination of EGCG and Caffeine. However, the presence of Caffeine will get in the way of sleep. With Green Tea supplements, however, we do not have to worry about the effects of Caffeine on sleep!


TOP RECOMMENDED GREEN TEA EXTRACT STACKS

Not only is our Green Tea EGCG extract great as a stand alone supplement, it also goes really well with a large variety of supplements! To give you some ideas, here are five stacks, one for each benefit we discussed throughout this blog!

BRAIN HEALTH SUPPORT STACK WITH GREEN TEA EXTRACT

Dynamine Methylliberine Capsules

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Chocamine Cocoa Extract

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Green Tea supplements promote brain health through unique oxidation balancing effects that go particularly well with the oxidation and inflammation balancing effects of Curcumin. The issues with Curcumin, however, is that it’s bioavailability is fairly lacklustre. Due to this, we have developed a formulation of Curcumin with an interesting compound called Piperine, that is found in black pepper. Piperine helps significantly boost the absorption of Curcumin. However, it has also been shown that piperine helps boost EGCG bioavailability. Now that’s a win-win!

OXIDATIVE SUPPORT STACK WITH GREEN TEA EXTRACT

Dynamine Methylliberine Capsules

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Chocamine Cocoa Extract

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The unique oxidation balancing effects of Green Tea supplements goes particularly well with another highly comprehensive oxidation regulating supplement, Pomegranate extract! In particular, our Green Tea EGCG extract goes particularly well with our patented and highly potent Pomegranate extract called Pomella. The two together will really help balance oxidation levels throughout your body!

SKIN HEALTH SUPPORT STACK WITH GREEN TEA EXTRACT

Dynamine Methylliberine Capsules

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Chocamine Cocoa Extract

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As we discussed in the blog, Green Tea supplements have a very comprehensive effect on helping to promote skin health. To push these effects even further, we would recommend combining our Green Tea EGCG extract with Injuv. Injuv is a novel formulation of Hyaluronic acid, which has been shown to help promote skin suppleness and elasticity. Together with Green Tea EGCG, the two form a great combination for helping promote skin health!

METABOLIC HEALTH SUPPORT STACK WITH GREEN TEA EXTRACT

Dynamine Methylliberine Capsules

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Caffeine + L-Theanine Capsules

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We already hinted towards this stack a little bit in the blog! Green Tea EGCG goes great with a source of Caffeine to help further promote its fat burning effects. However, we like to take things a step further, and instead of Caffeine, we would recommend combining our Green Tea EGCG extract with Dynamine. Dynamine is very similar to Caffeine, yet provides a much bigger punch, and in combination with EGCG, potentially a much bigger fat burning effect!

MOOD SUPPORT STACK WITH GREEN TEA EXTRACT

Dynamine Methylliberine Capsules

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Caffeine + L-Theanine Capsules

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We can’t really take credit for this stack, as mother nature came up with this one a long, long time ago! Not only does the Camellia sinensis plant produce catechins, it also produces unique amino acids like L-Theanine. However, these amino acids are present at very low levels in normal Green Tea and thus do not contribute much to the overall effects profile. However, when you combine a large amount of L-Theanine with a large amount of EGCG, you get a very effective mood promoting stack! L-Theanine helps promote feelings of relaxation and stress-regulation which go great together with the similar effects profile of EGCG. However, both of these supplements produce their effects through different pathways, and thus, the combination works synergistically!

WANT MORE STACK IDEAS?

If you liked the above stacks, and would like more well researched and effective stacks, then we would recommend giving our stack guide a read! Here you will find over 70 different stacks to help you reach your goals!


BUY GREEN TEA EXTRACT SUPPLEMENTS FROM NOOTROPIC DEPOT

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Scoops: Nootropics Depot does not provide scoops or spoons with any of our products. Scoops are highly unreliable for accurate measuring. Scoops measure volume rather than weight which is problematic because all powders have different densities. A milligram scale is needed to accurately measure powder products.

Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Nootropics Depot is an online-based vendor of high quality nootropics, novel plant extracts, amino acids, fish oil, choline supplements, vitamins, and more based in Tempe Arizona. We were founded in 2013 when we realized the industry needed a trusted source for these products and someone to champion the change the supplement industry needs. We have our own in-house analytical testing lab with some of the best analytical chemists in the supplement industry. We are constantly striving to advance and improve the purity and analytical standards of not only the nootropics industry, but the larger supplement industry as a whole.