Dynamine Methylliberine: A Fast-Acting, Natural Ingredient That Boosts Focus and Energy

There are also a few interesting uric acid derivatives of the xanthines, the two most common, and currently available on the market are:

Dynamine Methylliberine, a purine alkaloid, is found in the kucha tea leaf. It has a similar molecular structure to theacrine (TeaCrine) which is another natural energy supplement that is believed to act in similar ways throughout the body. Methylliberine may enhance feelings of energy, mood and focus by activating receptors and neurotransmitters that are responsible for these effects. And like Caffeine, Dynamine Methylliberine has also been found to regulate adenosine receptors.

We initially stumbled upon Dynamine Methylliberine when our sister brand Natrium Health was in the initial stages of Dynamax research and development. Our goal was to develop one the best and most comprehensive Caffeine and L Theanine-based products we could produce. We acquired a collection of xanthines, xanthine derivatives and xanthine formulations. After compiling them, we still felt that it wasn’t delivering the punch we expected. So, we added just 100 mg of Dynamine to the mix. Surprisingly, Dynamine enhanced the blend pretty significantly and the effects were reported within 15 minutes. We were so pleased with it that we fast tracked development for this product and released it way ahead of schedule.

Since we are producing Dynamax with Dynamine, we had a lot of it in house. So we decided to experiment with it in isolation and in different formulations. Below are our thoughts on what Dynamine can achieve:

Dynamine In Isolation:

Dynamine Methylliberine taken alone is an interesting experience but can be a little lackluster if you are looking for a long lasting boost of energy. Dynamine is ideal as a late day/night pre-workout supplement because the effects are short lived. A Dynamine dosage of 100mg can help perk up mood and energy levels late in the day without interfering with sleep. Used this way, a dosage of 100mg can provide a subtle boost in energy levels, whereas a Dynamine dosage of 200mg packs a bigger punch. However, the stimulating effect that Dynamine Methylliberine provides is not as intense as caffeine. This is why some people who use Caffeine frequently may not find the effects to be as stimulating compared to Caffeine.

This is where Dynamine Methylliberine really shines, and this likely has a lot to do with its pharmacological profile. Most xanthine molecules produce stimulating effects by blocking adenosine receptors. Adenosine is a major neurotransmitter which is formed as a byproduct of various energy intensive processes throughout the body. Most processes in the body are powered by one primary energy molecule called Adenosine Triphosphate (ATP). When ATP gets used to generate energy, a phosphate group falls off. ATP then becomes Adenosine Diphosphate (ADP). ADP can interact with more phosphate groups to regenerate ATP or it can lose another phosphate group, which then becomes Adenosine Monophosphate (AMP). As you may have guessed at this point, AMP can also interact with phosphate groups to regenerate ADP (which can then generate ATP), or it can lose yet another phosphate group, at which point we are left with plain adenosine. Adenosine can also be created by the direct breakdown of ATP in the brain by enzymes called ectonucleotidases. It also appears that oxidative stress and inflammation can speed up the generation of adenosine. This free adenosine can then start to bind to adenosine receptors in the brain, which will gradually cause significant lethargy, making it very hard to stay awake. This is fantastic if it happens at night before bed. All of the energy we exerted throughout the day that has slowly led to a massive buildup of adenosine is now helping us fall asleep. During sleep, a lot of this adenosine gets broken down and we wake up feeling refreshed. However, adenosine can start to affect us far before sleep. This is why, when xanthines block adenosine receptors, we start feeling more awake and alert. Adenosine receptors also control the function of many other receptors throughout the brain such as norepinephrine and serotonin. By activating adenosine receptors, the activity of these receptors decreases, whereas blocking adenosine receptors, can increase the activity of these receptors.

So What Does Methylliberine Do Differently?

Instead of blocking adenosine receptors, Methylliberine appears to act as a negative allosteric modulator, which means that instead of producing effects by fully blocking adenosine receptors, Methylliberine produces its effects by decreasing the overall sensitivity of adenosine receptors. This ultimately means that more adenosine needs to bind to adenosine receptors in order to make us tired.

Methylliberine and Theacrine both appear to act as negative allosteric modulators on adenosine receptors. Negative allosteric modulators tend to produce less of a tolerance buildup which is likely why Theacrine and Dynamine Methylliberine appear to build tolerance much less quickly than Caffeine, which fully blocks adenosine receptors. This means that Dynamine Methylliberine can significantly enhance caffeine’s effects by allowing a smaller amount of caffeine to produce a blocking effect on adenosine receptors. The benefit to this is that individuals who are looking to increase the effects of Caffeine can do so without having to take more Caffeine, and without increasing jitteriness. In fact, a new clinical trial has revealed that Dynamine can extend the half-life of Caffeine by about two-fold! However, Caffeine did not alter the pharmacokinetics of Dynamine. This means that you can take less Caffeine when paired with Dynamine, and have a longer lasting Caffeine experience! You can see the data below!

Combining Dynamine With other Xanthines:

Because the majority of xanthines are adenosine receptor blockers, methylliberine can also help enhance their effects. For a smooth, gentle, effective pre-workout, consider stacking Dynamine with Chocamine Cocoa Extract. To increase the energy effects, combine 100mg of Dynamine with a cup of green tea, this also increases the effects of the xanthine profile in tea.  

If you are feeling bold, Dynamine methylliberine may even help elevate yerba mate tea which has a very comprehensive xanthine profile of its own. The two together create a very comprehensive yet smooth stimulating brew! As mentioned previously, Dynamine can kick your caffeine up a notch. Just 100mg of Dynamine added to your morning cup of coffee can help your coffee pack an even bigger punch!

Now, if you wanted to really maximize caffeine’s potential, the combination of Dynamine, Teacrine, and Caffeine together extended caffeine’s half-line by approximately three-fold! This can be seen in the data illustrated in the chart above.

As you may have noticed, aside from this blog and a few others available on the internet, there is not a whole lot of information to be found on Dynamine Methylliberine. Due to the fact that Dynamine Methyllierine is a fairly new ingredient that until recen ly has not been produced in large amounts, there is little information available on the internet about it. Lately, there have been some serious scientific innovations from Compound Solutions,which has granted us access to this unique and ground-breaking xanthine derivative. Compound Solutions is currently conducting controlled studies on Dynamine Methylliberine to gain a deeper knowledge of Dynamine Methylliberine.

Here at Nootropics Depot, we are also working on expanding our understanding of this unique energy booster and discovering beneficial combinations of Methylliberine with other novel natural ingredients. In the meantime, here’s a recipe below for an advanced pre-workout formulation that includes Dynamine Methylliberine!